Spatial Working Memory and Reference Memory of Brown Norway and WAG Rats in a Holeboard Discrimination Task |
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| Institution: | 1. Department of Population Medicine, University of Guelph, Guelph, ON, N1G 2W1 Canada;2. Department of Animal Biosciences, University of Guelph, Guelph, ON, N1G 2W1 Canada;3. Division of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster LA1 4YQ, United Kingdom;4. Department of Physics, Faculty of Science and Technology, Lancaster University, Lancaster LA1 4YQ, United Kingdom;5. Lancaster Environment Centre, Lancaster University, Lancaster LA1 4YQ, United Kingdom;1. School of Veterinary and Life Sciences, Murdoch University, Murdoch, Western Australia, Australia;2. Animal Care and Veterinary Services, University of Western Australia, Crawley, Western Australia, Australia;3. School of Mathematical Sciences, University of Adelaide, Adelaide, South Australia, Australia;4. School of Women’s and Infants’ Health, University of Western Australia, Crawley, Western Australia, Australia;5. Topcat Metrology Ltd, Little Downham, UK;1. Louisiana State University, Eunice, LA, USA;2. Akey Inc., Brookville, OH, USA;1. Programa de Pós-Graduação em Ciências Biológicas, Farmacologia e Terapêutica-Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;2. Departamento de Farmacologia, Instituto de CiênciasBásicas da Saúde (ICBS), Universidade Federal do Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil;3. Laboratório de Farmacologia da Dor e Neuromodulação, Investigações Pré-clínicas, Departamento de Farmacologia, ICBS, UFRGS, Porto Alegre, RS, Brazil;4. Programa de Pós-Graduação em Ciências Médicas, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil;5. Programa de Pós-Graduação em Ciências Biológicas, Fisiologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil;6. Universidade Federal do Pampa, São Gabriel, RS, Brazil;1. Department of Production Animal Medicine, University of Helsinki, Helsinki, Finland;2. Department of Equine and Small Animal Medicine, University of Helsinki, Helsinki, Finland;3. Department of Pharmacology, Drug Development and Therapeutics, University of Turku, Turku, Finland;4. Unit of Clinical Pharmacology, Turku University Hospital, Turku, Finland |
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| Abstract: | To determine whether working memory (WM) and reference memory (RM) represent different aspects of spatial memory, albino WAG rats and the pigmented Brown Norway rats were tested in the acquisition, retention, and reversal of spatial orientation tasks in the holeboard, which allows the simultaneous assessment of WM and RM. Putative nonmnemonic factors, such as the speed of visiting the holes or the development of a search strategy (preferred sequence of visiting the baited set of holes) were also evaluated because they might influence WM and RM performance. The WM performance of Brown Norway rats was generally worse than that of the WAG rats. The reverse was true for the RM performance. Correlation analysis supported the notion that these two measures are independent. Differences in the speed of visiting the holes and in the development of a preferred sequence of visiting the baited set of holes could not explain the strain differences in WM and RM performance. Because spatial WM and RM appear to be independent measures in the holeboard, this task could be used to investigate whether different neural substrate(s) underlie these two memory components. |
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