Breast and Ovarian Cancer: The Forgotten Paternal Contribution |
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| Authors: | Email author" target="_blank">Jeanna?M?McCuaigEmail author Celia?M?T?Greenwood Cheryl?Shuman David?Chitayat K?Joan?Murphy Barry?Rosen Susan?Randall?Armel |
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| Institution: | (1) Division of Gynecologic Oncology, Princess Margaret Hospital - University Health Network, Toronto, Canada;(2) Department of Molecular Genetics, University of Toronto, Toronto, Canada;(3) Lady Davis Institute for Medical Research, Montreal, Canada;(4) Department of Oncology, McGill University, Montreal, Canada;(5) Department of Epidemiology, Biostatistics, and Occupational Health, McGill University, Montreal, Canada;(6) Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, Toronto, Canada;(7) Department of Obstetrics and Gynecology, University of Toronto, Toronto, Canada;(8) Department of Molecular Genetics, Mount Sinai Hospital, Toronto, Canada;(9) Familial Breast and Ovarian Cancer Clinic, Princess Margaret Hospital, M-704 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9 |
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| Abstract: | Five to 10% of all cases of breast and ovarian cancer are attributed to a heritable genetic predisposition. Transmission of
BRCA1 and BRCA2 mutations is equally likely through maternal or paternal lineage; however, fewer referrals to cancer genetics clinics appear
to be made for a paternal, than maternal, family history of breast and/or ovarian cancer. To examine this potential bias,
a retrospective review of 315 patient and family charts was conducted by one familial cancer clinic in Toronto, Canada. Referral
letters, risk estimates, and family histories were analyzed to identify significant differences between patients referred
with maternal and paternal family histories. It was determined that patients are approximately five times more likely to be
referred with a maternal family history of breast and/or ovarian cancer as compared to those with a paternal family history
(p = <.0001). Individuals with a paternal family history were found to have a different, and higher, pattern of risk estimates
(p = .00064). No significant difference was seen between the type of referrals sent by general practitioners, oncologists, and
gynecologists. Recommendations to increase the awareness of paternal family history in assessing cancer risk are provided. |
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