Neuropsychological and Behavioral Effects of Antiepilepsy Drugs |
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| Authors: | David W Loring Susan Marino Kimford J Meador |
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| Institution: | (1) Department of Neurology, University of Florida, Gainesville, USA;(2) Department of Clinical and Health Psychology, University of Florida, Gainesville, USA;(3) Department of Pharmacy Practice, University of Florida, Gainesville, USA;(4) McKnight Brain Institute, University of Florida, P.O. Box 100236, Gainesville, FL 32610-0236, USA |
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| Abstract: | Antiepilepsy drugs work by decreasing neuronal irritability, which may also result in the non-desired side effect of decreased
neuropsychological function. In addition to cognitive side effects, antiepilepsy drugs (AEDs) may be associated with behavioral
effects which may range from irritability and hyperactivity to positive psychotropic effects on mood. There have been many
new medications released since the 1990s, and although they tend to have more favorable side effect profiles compared to their
older counterparts, there continues to be a risk of decreased cognitive function with the majority of these agents. The effects
of in utero antiepilepsy drug exposure are increasingly being investigated, and differential drug risk is beginning to be
described for both anatomic and cognitive outcomes. Patients with epilepsy undergoing neuropsychological evaluations are commonly
on AEDs, and it is important for the clinician to recognize the potential contribution of AED therapy to neuropsychological
profiles. The present article serves to provide an overview of our current understanding regarding the risks of antiepilepsy
drug use for both cognitive and behavioral side effects. |
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| Keywords: | Antiepilepsy drugs Neuropsychological Cognitive and behavioral side effects |
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