银屑病发病的心理社会因素及危险因素间关系的探讨——非条件Logistic回归分析和通径分析

本文对97例寻常型银屑病患者以及71例皮肤科对照组患者进行了成组病例对照性研究。相对危险度分析从36个研究因素中筛选出14项可疑危险因素;非条件Logistic回归分析提示其中8项因素有明显的致病意义;结合专业知识,对这8项危险因素进行通径分析。研究结果表明,银屑病发病是多因素综合作用的结果,心理社会危险因素通过直接或/和间接(联合)作用,影响致病过程。经通径图将各因素的作用大小、作用形式及协同作用关系较直观地描绘出来。

A CASE-CONTROL STUDY ON PSYCHOSOCIAL RISK FACTORS OF PSORIASIS-NON-CONDITIONAL LOGISTIC REGRESSION ANALYSIS AND PATH ANALYSIS

A case-control study has been carried out on 97 vulgaris psoriasis patients as experimental group compared with 71 dermatological patients withoutpsoriasis as the control group, they were matched for age, sex, occupation,educational level, economic status and residental conditions. 36 variables, con-sisting of 26 psychosocial ratings (MMPI, EPQ, SCL-90 and LES), 7 bio-logical indices and 3 environmental factors, had (Relative Risk), and then14 variables were confirmed as the risk factors on developing psoriasis, TheNon-conditional Logistic Regression Analysis showed that 8 of the 14 varia-bles were associated with developing psoriasis significantly. According topsychology and dermatology knowledge, the causal structure recursive modelof Path Analysis with 8 risk factors for psoriasis was set up. The resultsindicated that 5 psychosocial factors had direct or indirect influence on theoccurence of psoriasis respectively. The path diagram drew the relation ofcoopetation effects among 8 risk factors.