Repeated measurements analysis of variance when the correlations have a certain pattern

Consider a repeated measurements study in which a single observation is taken at each oft(t > 2) equally spaced time points for each ofn subjects. This paper uses a result of Box to find the appropriate multiplicative correction term for the degrees of freedom in the analysis of variance table for the case when there is equal variability per time point, and when the correlation between observationsu time units apart is equal to ^u. For large values oft, the multiplicative correction has a lower bound approximately equal to 2.5/(t – 1).Dr. Fleiss is also with the Biometrics Research Unit of the New York State Psychiatric Institute. This work was supported in part by grant DE 04068 from the National Institute of Dental Research.