| DNMT1和PDCD4在胃癌中的表达及其临床意义 |
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| 引用本文： | 孙娜,卢雪峰,刘胜楠,郑雪婷,李倩倩. DNMT1和PDCD4在胃癌中的表达及其临床意义[J]. 医学与哲学(人文社会医学版), 2011, 0(11): 54-56 |
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| 作者姓名： | 孙娜 卢雪峰 刘胜楠 郑雪婷 李倩倩 |
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| 作者单位： | [1]山东大学医学院,山东济南250012 [2]山东大学齐鲁医院消化内科,山东济南250012 |
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| 摘 要： | 为探讨DNMT1和PDCD4在胃癌中的表达及其临床意义，采用免疫组织化学SP法检测62例胃腺癌、36例上皮内瘤变、27例肠上皮化生及20例正常胃黏膜中DNMT1和PDCD4的表达水平，并探讨其与临床病理学参数的关系。结果DNMT1在胃腺癌中呈高表达，PDCD4呈低表达，二者的表达呈明显负相关（P=0．000）；DNMT...
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| 关 键 词： | DNA甲基化转移酶1 程序性细胞死亡因子4 胃癌 |
Expression and Significance of PDCD4 and DNMT1 in Gastric Carcinoma |
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| Affiliation: | SUN Na, LU Xue-feng, LIU Sheng-nan, et al. The Gastroenterology of Qilu Hospital of Shandong University ,Jinan 250012,China |
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| Abstract: | To investigate the expression of DNMT1 and PDCD4 in human gastric carcinoma and their clinical significance, applying immunohistochemical staining method, the expressions of DNMT1 and PDCD4 were detected in the samples of gastric ＂adenocarcinoma（ n= 62） ,intraepithelial neoplasia （ n= 36） ,intestinal metaplasia（n= 27） and normal gastric mucosa （ n= 20） ,and the correlations between DNMT1, PDCD4 and clinical pathological parameters were analyzed. There was a significant overexpression of DNMT1 in gastric adenocarcinoma, nevertheless, the expression of PDCD4 is at a low lever. There was a negative correlation between DNMT1 and PDCD4（P= 0. 000）. The expression rates of DNMT1 and PDCD4 were related closely to tumor differentiation（ P〈0.05）. Therefore,the abnormal expression of PDCD4 and DNMT1 might play an important role in occurrence and development of gastric carcinoma, DNMT1 may participate in the inactivation of PDCD4 expression through methylation mechanism. |
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| Keywords: | DNMT1 PDCD4 gastric carcinoma |
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