Activation of adenosine receptors in the posterior cingulate cortex impairs memory retrieval in the rat |
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Authors: | Pereira Grace Schenatto Rossato Janine Inez Sarkis João José Freitas Cammarota Martín Bonan Carla Denise Izquierdo Iván |
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Affiliation: | Instituto de Pesquisas Biomédicas, Pontifícia universidade Católica do Rio Grande do Sul, Porto Alegre, Rs, Brazil.graceschenatto@hotmail.com |
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Abstract: | Adenosine A1 and A2A receptor agonists and antagonists have been reported to alter learning and memory. The aim of our study was to investigate the involvement of adenosinergic system in memory retrieval into posterior cingulate cortex (PCC) of Wistar rats. To clarify this question, we tested specifics agonist and antagonists of adenosine A1 and A2A receptors in rats submitted to a one-trial inhibitory avoidance task. The stimulation of adenosine A1 and A2A receptors by CPA and CGS21680, respectively, impaired memory retrieval for inhibitory avoidance task, into PCC. These findings provide behavioral evidence for the role of adenosinergic system in the memory retrieval into PCC. |
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Keywords: | Adenosine A1 receptor Adenosine A2A receptor Retrieval Memory Posterior cingulate cortex Inhibitory avoidance task |
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