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Inhibitory Control in Children with Frontal Infarcts Related to Sickle Cell Disease |
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| Authors: | Shawn E. Christ Asif Moinuddin Robert C. McKinstry Michael DeBaun Desirée A. White |
| Affiliation: | 1. Department of Psychology , Washington University , St. Louis, MO, USA;2. Department of Psychological Sciences , University of Missouri , Columbia, MO, USA research@shawnchrist.com;4. Mallinckrodt Institute of Radiology, Washington University School of Medicine , St. Louis, MO, USA;5. Department of Pediatrics , Division of Hematology/Oncology St. Louis Children's Hospital at the Washington University Medical Center , St. Louis, MO, USA;6. Department of Psychology , Washington University , St. Louis, MO, USA |
| Abstract: | Evidence from past studies indicates that children with traumatic brain injury experience difficulties with inhibitory control. Less is known about inhibitory control in children with frontal brain injury related to cerebral infarction. We compared the inhibitory performance of children with frontal infarcts related to sickle cell disease with that of a control group of children with sickle cell disease but no history of cerebral infarction. On a stimulus-response reversal task, children with frontal infarcts made significantly more accuracy errors in the inhibitory condition than controls. Findings from this study and from previous research suggest that impairments in inhibitory control are common following frontal injury in a range of pediatric populations. |
| Keywords: | Inhibitory control executive ability neuropsychology cognition frontal cortex children sickle cell disease |