MR Diffusion Tensor Imaging: A Window into White Matter Integrity of the Working Brain |
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Authors: | Sandra Chanraud Natalie Zahr Edith V Sullivan Adolf Pfefferbaum |
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Institution: | (1) Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine (MC5723), 401 Quarry Road, Stanford, CA 94305-5723, USA;(2) Neuroscience Program, SRI International, 333 Ravenswood Rd., Menlo Park, CA, USA; |
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Abstract: | As Norman Geschwind asserted in 1965, syndromes resulting from white matter lesions could produce deficits in higher-order
functions and “disconnexion” or the interruption of connection between gray matter regions could be as disruptive as trauma
to those regions per se. The advent of in vivo diffusion tensor imaging, which allows quantitative characterization of white
matter fiber integrity in health and disease, has served to strengthen Geschwind’s proposal. Here we present an overview of
the principles of diffusion tensor imaging (DTI) and its contribution to progress in our current understanding of normal and
pathological brain function. |
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