某院3年医院感染患者细菌分离及耐药性分析

应用WHONET5．3软件对2005年1月至2007年12月检出的1749株病原菌种类、分布及其耐药性进行统计分析。结果发现院内感染病原菌以条件致病菌为主，革兰阴性菌检出率61．8％，革兰阳性菌的检出率33％，真菌检出率为5．2％。大肠埃希菌及肺炎克雷伯菌属的ESBLs阳性率分别为34．4％和48．9％，MRSA和MRCNS的检出率分别为40．8％和36．4％。大多数病原菌对抗生素产生多重耐药性。由此可见，由于临床抗生素的广泛使用，病原菌不断变迁且其耐药性逐渐上升，应加强耐药性监测及合理使用抗生素，以有效控制细菌感染和耐药性播散。

Surveillance of Clinical Bacterial Isolates and Bacterial Resistance in a Hospital in 3 Years

To investigate the pathogens of nosocomial infection and its drug resistance of 1749 positive specimens during 2005.01 to 2007.12 were analyzed with WHONETS. 3 software. The conditional pathogenic bacteria is the primary pathogenic bacteria of the nosocomial infection, the detection rates of bacteria with negative and positive Gram staining is 61.8 % and 33% ,respectively,and 5.2% for fungi. The positive rates of ESBLs E. coli and K. pneumoniae was 34.4% and 48. 9%. The rates of MRSA and MRCNS was 40. 8% and 36. 4%. Most of bacteria of nosocomial infection in this study showed multiple resistances to antibiotics. Due to the unreasonable use of antibiotics and variation of bacteria, the drug resistance was rapidly increasing,We should detect the resistant bacteria rapidly and use antibiotic rationally,so as to control the dissemination of bacterial infection and its resistance.