Explanatory models of muscle performance in acromegaly patients evaluated by knee isokinetic dynamometry: Implications for rehabilitation |
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| Affiliation: | 1. Endocrinology Unit, Medical Department, Azienda Usl Bologna Maggiore-Bellaria Hospital, Bologna, Italy;2. Sexual Medicine and Andrology Unit, Department of Experimental, Clinical, and Biomedical Sciences, University of Florence, Florence, Italy;3. School of Sexology, Department of Clinical, Applied, and Biotechnological Sciences, University of L’Aquila, L’Aquila, Italy;4. Endocrinology, Andrology, and Medical Sexology, Department of Systems Medicine, Tor Vergata University of Rome, Rome, Italy;1. School of Rehabilitation Sciences, University of Ottawa, 200 Lees Avenue Ottawa, ON K1N 6N5, Canada;2. School of Human Kinetics, University of Ottawa, 200 Lees Avenue Ottawa, ON K1N 6N5, Canada;3. Department of Biomedical Sciences, University of Copenhagen, Blegdamsvej 3, 2200 Copenhagen N, Denmark;4. Department of Clinical Medicine, University of Copenhagen, Blegdamsvej 2, 2200 Copenhagen N, Denmark;5. Section for Sports Traumatology M51, Bispebjerg-Frederiksberg, Hospital, Denmark;6. Member of IOC Sports Medicine Copnehagen;1. School of Healthcare Science, Manchester Metropolitan University, Manchester, UK;2. Department of Human Movement Sciences, Faculty of Behavioural and Movement Sciences, Vrije University Amsterdam, Amsterdam Movement Sciences, The Netherlands;3. Institute of Sport Science and Innovations, Lithuanian Sports University Kaunas, Lithuania |
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| Abstract: | PurposeTo evaluate the effects of demographics and hormonal variations on knee muscle performance in patients with acromegaly and develop explanatory models of peripheral muscle function in these individuals.MethodsThis was a cross-sectional study in which 53 acromegalics and 27 healthy subjects underwent knee isokinetic dynamometry to evaluate the peak torque value for leg extension at 75°/s (PTE75) and 240°/s (PTE240). Separate multivariable linear regression models for the prediction of PTE75 and PTE240 were tested using variables commonly used as predictors in the clinical setting and other specific variables related to acromegaly.ResultsThe final prediction model for PTE75 (R2 = 0.888; adjusted R2 = 0.820, SE of bias = 16.2 Nm, p < 0.001) was −0.221 × growth hormone + 36.791 × sexmale = 1 − 27.407 × statusactive = 1 − 0.690 × age + 148.071. The final prediction model for PTE240 (R2 = 0.816; adjusted R2 = 0.805, SE of bias = 8.8 Nm, p < 0.001) was −0.174 × growth hormone + 12.522 × sexmale = 1 − 0.520 × age + 98.099.ConclusionsIn acromegalics, high growth hormone levels, female gender, and older age are associated with reduced muscle strength and endurance. Additionally, active disease negatively affects peripheral muscle strength in these patients. |
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| Keywords: | Acromegaly Muscle strength Rehabilitation |
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