Investigation of factors impacting mobility and gait in Parkinson disease |
| |
| Affiliation: | 1. Federal University of Mato Grosso do Sul, Program in Health and Development, Campo Grande, MS 79060-900, Brazil;2. Washington University School of Medicine in Saint Louis, Program in Physical Therapy, St. Louis, MO 63108, USA;3. Washington University School of Medicine in Saint Louis, Department of Neurology, St. Louis, MO 63110, USA;4. Washington University School of Medicine in Saint Louis, Department of Radiology, St. Louis, MO 63110, USA;5. Washington University School of Medicine in Saint Louis, Department of Neuroscience, St. Louis, MO 63110, USA;1. Parkinson''s Disease Research Clinic, Brain and Mind Research Institute, University of Sydney, NSW, Australia;2. Centre for Human Movement Sciences, University Medical Centre Groningen, University of Groningen, Groningen, the Netherlands;3. Healthy Brain Ageing Program, Ageing Brain Centre, Brain and Mind Research Institute, University of Sydney, NSW, Australia;1. CIUSSS du Centre-Sud-de-l’Île-de-Montréal (Installation Gingras-Lindsay), Montreal, QC, Canada;2. Pathokinesiology Laboratory, Centre for Interdisciplinary Research in Rehabilitation of Greater Montreal, Institut universitaire sur la réadaptation en déficience physique de Montréal (IURDPM), Montreal, QC, Canada;3. School of Rehabilitation, Université de Montréal, Montreal, QC Canada;4. Toronto Rehabilitation Institute–Lyndhurst Centre, Toronto, ON, Canada;1. Department of Applied Physiology & Kinesiology, University of Florida, Gainesville, FL, USA;2. Department of Speech, Language, and Hearing Sciences, University of Florida, Gainesville, FL, USA;3. Department of Neurology, University of Florida, Gainesville, FL, USA;4. Center for Movement Disorders and Neurorestoration, Gainesville, FL, USA |
| |
| Abstract: | Mobility and gait limitations are major issues for people with Parkinson disease (PD). Identification of factors that contribute to these impairments may inform treatment and intervention strategies. In this study we investigated factors that predict mobility and gait impairment in PD. Participants with mild to moderate PD and without dementia (n = 114) were tested in one session ‘off’ medication. Mobility measures included the 6-Minute Walk test and Timed-Up-and-Go. Gait velocity was collected in four conditions: forward preferred speed, forward dual task, forward fast as possible and backward walking. The predictors analyzed were age, gender, disease severity, balance, balance confidence, fall history, self-reported physical activity, and executive function. Multiple regression models were used to assess the relationships between predictors and outcomes. The predictors, in different combinations for each outcome measure, explained 55.7% to 66.9% of variability for mobility and 39.5% to 52.8% for gait velocity. Balance was the most relevant factor (explaining up to 54.1% of variance in mobility and up to 45.6% in gait velocity). Balance confidence contributed to a lesser extent (2.0% to 8.2% of variance) in all models. Age explained a small percentage of variance in mobility and gait velocity (up to 2.9%). Executive function explained 3.0% of variance during forward walking only. The strong predictive relationships between balance deficits and mobility and gait impairment suggest targeting balance deficits may be particularly important for improving mobility and gait in people with PD, regardless of an individual’s age, disease severity, fall history, or other demographic features. |
| |
| Keywords: | Parkinson disease Mobility Gait Balance Disease severity Executive function |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
