疼痛恐惧的形成及其对疼痛知觉的影响

脑岛、杏仁核是疼痛恐惧形成的重要神经网络中心。疼痛恐惧增强了慢性疼痛患者的疼痛知觉体验, 进而加剧抑郁、焦虑情绪和功能损伤程度。脑岛、杏仁核、前额皮层和前扣带回是疼痛恐惧影响疼痛知觉的重要神经基础。通过认知方法干预疼痛恐惧可以改善患者的抑郁、焦虑情绪, 减少功能损伤。未来研究应拓展疼痛恐惧的测量工具, 采用功能磁共振成像技术进一步揭示疼痛恐惧影响慢性疼痛患者疼痛知觉的神经机制。

The formulation of fear of pain and its influence on pain perception

Insula and amygdala are crucial neural network center for the formulation of fear of pain (FOP).FOP exacerbates pain perceptual experiences in patients with chronic pain,and then enhances their depression,anxiety and functional disability.Insular,amygdala,prefrontal cortex,and anterior cingulate cortex are crucial neural substrates for the impact of FOP on pain perception.Reducing FOP by using cognitive intervention therapies can effectively decrease pain experience in patients with chronic pain,and improve their depression,anxiety problems,and daily function.Future studies should develop new measurement tools to assess FOP,and furthermore to reveal the neural mechanisms about the impact of FOP on pain perception in patients with chronic pain by using the functional magnetic resonance imaging technology.