Effect of catatoxic steroids upon lidocaine intoxication

Various steroids have been shown to influence the activity of psychotropic hormones and drugs. Among these, we distinguish “syntoxic” steroids which act by inhibiting excessive reactions to various agents and “catatoxic” steroids which actually destroy certain toxicants and hormones often through the induction of hepatic microsomal enzymes. Thus, the liver can play a decisive role in psychosomatic interrelations by regulating the blood clearance of agents affecting the nervous system. To illustrate these principles, new observations are presented which show that certain catatoxic steroids offer considerable protection against lidocaine, an anesthetic, analgesic drug. These findings may serve as an example showing how modern research techniques may help us to analyze the possible relationships between the liver and the mind, which were intuitively suspected since Hippocrates created the term “melancholia.”