Cued recall in anterograde amnesia

After a single presentation of a word list, normal subjects exhibited better retention when prompted with semantic cues than with rhyme or letter cues. Alcoholic Korsakoff patients, patients receiving electroconvulsive therapy (ECT), and the patient N.A. exhibited impaired retention and, unlike control subjects, did not exhibit an advantage of semantic cues over letter and rhyme cues. Two experimental manipulations designed to equate the level of performance of amnesics and controls indicated that these amnesias could be understood as a reflection of weak memory strength that results from deficiencies in initial learning and retention. In addition, alcoholic Korsakoff patients appeared to have greater difficulty utilizing semantic cues than patients receiving ECT or patient N.A.