Conditioned inhibition of cyclophosphamide-induced taste aversion |
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Authors: | Lambert Joseph V Whitehouse Wayne G |
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Affiliation: | Department of Social Sciences, University of the Sciences in Philadelphia, PA 19104, USA. j.lamber@usip.edu |
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Abstract: | Rats in an experimental group received trials during which 1 flavor (saccharin) was always followed by cyclophosphamide, an immunosuppressive drug, but another (vanilla) was not. An unconditioned stimulus-only group served as a control. Flavor-preference tests revealed that conditioned excitation and conditioned inhibition occurred in the conditioned group subjects but not in the control group subjects. This demonstration suggests that a conditioned inhibitor might be used to modify conditioned and unconditioned immune system functions, for example, natural killer-cell activity. |
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