Conditioned inhibition of cocaine seeking in rats |
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Authors: | Kearns David N Weiss Stanley J Schindler Charles W Panlilio Leigh V |
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Affiliation: | Department of Psychology, American University, Washington, DC 20016, USA. dk0085a@american.edu |
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Abstract: | Despite its potential relevance to the treatment of drug abuse, conditioned inhibition of drug seeking has not been systematically investigated before. In this study, rats could self-administer cocaine by lever pressing whenever a click or tone was present. Responding was not reinforced when a light was present. The light was presented simultaneously with the click (i.e., in an excitatory context) in 1 group, but the light was always presented alone in another group. When it was later presented in compound with the tone, the light was a highly effective conditioned inhibitor, suppressing cocaine seeking by 92% in the former group and by 74% in the latter. These results suggest ways to improve cue-oriented behavioral treatments for drug abuse. |
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