5-HT2A: its role in frontally mediated executive function and related psychopathology |
| |
Authors: | Stein Dan J Hemmings Sian Moolman-Smook Hanlie Audenaert Kurt |
| |
Affiliation: | Department of Mental Health and Psychiatry, University of Cape Town, South Africa. |
| |
Abstract: | Serotonin (5-HT)2A receptors are widely distributed, with high levels in the frontal cortex, where postsynaptic activation may increase activity in pyramidal glutamatergic neurons and mediate various executive functions. More specifically, reciprocal cortical-raphe pathways may allow the ventral prefrontal cortex to inhibit stress-induced neural activity in the brainstem when stressors are perceived as controllable. However, early adversity and negative attitudes may be associated with higher frontal 5-HT2A receptor levels and greater risk for stress-induced psychopathology, and certain 5-HT2A gene variants have been associated with increased risk for impulsive behavior. Conversely, many antidepressants result in decreased levels of 5-HT2A receptor levels, and blockade of 5-HT2A receptors has proven useful in the treatment of a number of psychiatric disorders. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|