Cortical spreading depression and conditioned taste aversion: an attempt to resolve a controversy |
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| Authors: | J L Davis O Buresova J Bures |
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| Affiliation: | 1. Department of Neurobiology, Weizmann Institute of Science, Rehovot 76100, Israel;2. Friedrich Miescher Institute for Biomedical Research, Basel, 4058, Switzerland;3. Center for Molecular Neurobiology Hamburg, Hamburg 20251, Germany;4. LIMES Institute, University of Bonn, Bonn 53115, Germany;5. Charité-Universitätsmedizin Berlin, Berlin 10117, Germany;6. German Center for Neurodegenerative Diseases (DZNE), Berlin 10117, Germany;7. Bernstein Center for Computational Neuroscience, Berlin 10115, Germany;8. Cluster of Excellence NeuroCure, Berlin 10117, Germany;9. Einstein Center for Neurosciences Berlin, Berlin 10117, Germany;10. Max-Delbrück Center for Molecular Medicine, Berlin 13125, Germany;1. International Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan;2. Department of Neurophysiology, Graduate School of Medicine, The University of Tokyo, Tokyo 113-0033, Japan;3. International Research Center for Neurointelligence (WPI-IRCN), The University of Tokyo Institutes for Advanced Study (UTIAS), Tokyo 113-0033, Japan;4. Department of Pediatrics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA;5. Department of Genome Biology, Faculty of Medicine, University of Tsukuba, Tsukuba, Ibaraki 305-0006, Japan;6. Graduate School of Information Science and Technology, The University of Tokyo, Tokyo 113-8656, Japan;7. Emotional Brain Institute, Nathan Kline Institute, Orangeburg, NY 10962, USA;8. Centre for Clinical Brain Sciences, Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh EH16 4SB, UK;9. Department of Developmental and Regenerative Biology, Institute of Brain Science, Nagoya City University Graduate School of Medical Sciences, Nagoya, Aichi 467-8601, Japan;10. Division of Neural Development and Regeneration, National Institute for Physiological Sciences, Okazaki, Aichi 444-8585, Japan;11. RIKEN Center for Brain Science, Wako, Saitama 351-0106, Japan;1. Edmond and Lily Safra Center for Brain Sciences (ELSC), The Hebrew University of Jerusalem, Jerusalem 91904, Israel;2. ELSC Vector Core Facility, The Hebrew University of Jerusalem, Jerusalem 91904, Israel;3. Alexander Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel;1. Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA;2. Department of Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC 27710, USA;3. Department of Neurobiology, Duke University Medical Center, Durham, NC 27710, USA;4. Department of Neurosurgery, Duke University Medical Center, Durham, NC 27710, USA;5. Department of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC 27710, USA;6. Department of Biochemistry, Duke University Medical Center, Durham, NC 27710, USA;7. Department of Pediatrics, Duke University Medical Center, Durham, NC 27710, USA;8. Department of Neurology, Duke University Medical Center, Durham, NC 27710, USA;9. Department of Molecular Physiology and Biophysics, Psychiatry, University of Iowa, Iowa City, IA 52242, USA;10. Department of Statistical Science, Duke University, Durham, NC 27708, USA;11. Department of Civil and Environmental Engineering, Duke University, Durham, NC 27708, USA;12. Department of Biomedical Engineering, Duke University, Durham, NC 27708, USA;1. Department of Physics, Princeton University, Jadwin Hall, Princeton, NJ 08544, USA;2. Princeton Neuroscience Institute, Princeton University, Princeton, NJ 08544, USA |
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| Abstract: | The claim (Winn, Todd, & Elias, Behav. Biol. 19, 55-63 (1977) ) that cortical spreading depression (CSD) can serve as US in the conditioned taste-aversion (CTA) paradigm was experimentally examined. Rats given 15-min access to novel 0.1% sodium saccharin (CS) followed by ip NaCl and bilateral or unilateral CSD (US) displayed similar saccharin preference (54%) as the sham-CSD-treated controls in a multiple-bottle retention test. Rats receiving ip LiCl (0.15 M, 2% body weight) and sham CSD as the US showed marked saccharin aversion. It is concluded that CSD does not elicit CTA and that some claims to the contrary can perhaps be ascribed to CSD-induced disruption of attenuation of neophobia. |
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