Association between the HTR2B gene and the personality trait of fun seeking |
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| Institution: | 1. State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, China;2. Department of Psychology and Social Behavior, University of California, Irvine, USA;3. Department of Biological Chemistry and Institute of Genomics and Bioinformatics, University of California, Irvine, USA;1. University of Bern, Switzerland;2. Stanford University School of Medicine, USA;3. University of Pennsylvania, USA;4. Oregon Health and Science University, Oregon, USA;5. University of Auckland, New Zealand;6. Hackensack University Medical Center, NJ, USA;7. University of California, San Diego, USA;8. University of Western Ontario, Ontario, Canada;9. University of Jena, Germany;10. University of Illinois at Urbana-Champaign, IL, USA;11. Institute for Systems Biology, USA;12. University of Sydney, Australia;13. North Carolina State University, USA;14. Magee-Women''s Research Institute, PA, USA;15. University of Queensland, QLD Australia;p. Iowa State University, IA, USA;q. University of British Columbia, Canada;r. Center for Reproductive Health, MetroHealth Medical Center, Case Western Reserve University, Cleveland, OH, USA;1. Department of Endocrinology, University of Ioannina, 45110 Ioannina, Greece;2. Laboratory of Human Reproductive Genetics, Department of Obstetrics and Gynaecology, University of Ioannina, 45110 Ioannina, Greece;1. Department of Acupuncture and Moxibustion, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China;1. Picower Institute for Learning and Memory, Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Department of Transfusion, Peking University Shenzhen Hospital, Shenzhen PKU-HKUST Medical Center, Shenzhen;3. School of Computer Science and Technology, Tianjin University, Tianjin;4. Guangdong Provincial Key Laboratory of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China;6. State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai;5. Stanley Ho Centre for Emerging Infectious Diseases, Li Ka Shing Institute of Medical Sciences, The Chinese University of Hong Kong, Hong Kong;11. Center for Clinical Medical Research, Department of Cancer, Shandong Provincial Zibo Central Hospital, Zibo, China;12. Institute of Molecular Medicine and Genetics, Georgia Regents University, Augusta, GA |
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| Abstract: | Previous research reported that a rare serotonin receptor 2B gene (HTR2B) stop codon mutation predisposes subjects to severe impulsivity and novelty seeking. In this study, we expanded this previous work by testing six single nucleotide polymorphisms (SNPs) within the HTR2B gene for potential associations with the behavioral inhibition system (BIS) and the three components of the behavioral approach systems (BAS: fun seeking, drive, and reward responsiveness) in a Han Chinese sample (N = 478). Association analysis for individual SNPs indicated that four of the six SNPs (i.e., rs6437000, rs10194776, rs16827801, and rs1549339) were significantly associated with BAS fun seeking (p = .0003–.0022). Haplotype-based association analysis revealed that fun seeking was positively associated with haplotype A–A–G–A for SNPs rs6437000–rs10194776–rs16827801–rs1549339 (p = .0002), which survived Bonferroni correction. Except for the association between BAS reward responsiveness and rs16827801 (p = .005), no other association was found for BAS drive, BAS reward responsiveness, or BIS. This study provides the first evidence for the involvement of the HTR2B gene in BAS fun seeking. A better understanding of the genetic basis of the BIS and BAS would allow us to develop more effective diagnosis, treatment, and prevention of impulsive behavioral problems. |
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