Neural Circuitry Associated with Risk for Alcohol Use Disorders |
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Authors: | Kevin D Tessner Shirley Y Hill |
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Institution: | (1) Department of Psychiatry, University of Pittsburgh School of Medicine, 3811 O’ Hara St., Pittsburgh, PA 15213, USA |
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Abstract: | The core features of risk for alcohol use disorders (AUD), including behavioral disinhibition, affective dysregulation, and
executive dysfunction, map onto distinct neural circuits that have been found to be abnormal in the offspring of alcohol dependent
individuals. Components of the cerebellothalamocortical system and the extended limbic network may provide the underpinnings
for the behavioral and emotional dysfunction observed in individuals at heightened risk for AUD. In addition, abnormalities
in these structures appear to be altered in individuals with the predisposition for other psychiatric conditions that may
share a similar genetic diathesis. This review proposes several neurobehavioral mechanisms of genetic vulnerability that may
account for phenotypic characteristics in individuals at risk for AUD. |
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Keywords: | |
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