The anatomy of madness: Psychosis as functional hippocampal afterdischarge

Psychosis is viewed theoretically as hippocampal seizure and afterdischarge resulting from conditions of stressful stimulation and/or inhibitory disinhibition. Key anatomical structures involved and their dynamic interrelationships in health and psychosis are discussed. Several pathological physical conditions as well as certain autostimulatory behavior are seen as contributory or perpetuating to this condition.