Psychopharmacologic facilitation of operant conditioning of genetically nervous catahoula and Pointer dogs

Previous work has demonstrated that a genetic factor underlies much of the disturbed behavior in one strain of short haired pointer bird dogs (E line) maintained for several years in our laboratory. In some dogs the behavior is seemingly permanent and is characterized by human avoidance, excessive startle, reduced exploratory activity, and “freezing” or catatonic posturing. Another strain of dogs, catahoulas, with a high incidence of disturbed behavior similar to that above but with much less catatonic posturing, was made available for study also. In both of these strains defensive reaction and gross avoidance behavior often prevents the acquisition and later performance of operant conditioning (bar pressing for food reward) unless supportive tranquilizing chemotherapy is given. The chief interest in this study is, (1) the nearly permanent disharmony in the animal which seems to be an example of Gantt’s concept of schizokinesis, and (2) a comparison of 12 psychoactive compounds widely used in psychiatry for their effectiveness in restoring integrated adaptive functioning even in the most disturbed of the animals in our colony. The results show that: 1. even dogs with the most severe schizokinetic disabilities of many years duration have learned the operant conditioning (bar pressing); 2. however, it was and has remained necessary to facilitate both behavior shaping and nearly all later performances throughout the following year with benzodiazepine tranquilizers and these were far superior to any of the several other drugs tested; 3. neither gradual or rapid withdrawal nor sudden stopping of benzodiazepines allowed the dogs to continue the bar pressing. In fact, during withdrawal of the drug, performance seemed to parallel blood levels as reported in the literature.