Sentence Comprehension Deficits in Alzheimer's Disease: A Comparison of Off-Line vs. On-Line Sentence Processing |
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| Authors: | Daniel Kempler Amit Almor Lorraine K. Tyler Elaine S. Andersen Maryellen C. MacDonald |
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| Affiliation: | aProgram in Neural, Informational and Behavioral Sciences, University of Southern California;bDepartment of Otolaryngology, University of Southern California;cSchool of Gerontology, University of Southern California;dDepartment of Psychology, University of Southern California;fDepartment of Linguistics, University of Southern California;eDepartment of Psychology, Birkbeck College, University of London, United Kingdom |
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| Abstract: | Two studies explored whether sentence comprehension impairments in Alzheimer's disease (AD) are due to deficits in syntactic processing or memory. Study 1 used a picture-pointing sentence comprehension task to measure the final outcome of comprehension in an off-line fashion. It showed the comprehension of 30 patients with AD to be impaired, but suggested that the deficits could not be attributed solely to syntactic impairments. Study 2 investigated the effects of memory on sentence comprehension by comparing off-line (grammaticality judgment) with on-line (cross-modal naming) language processing in 11 AD and 9 control subjects. The results revealed impaired performance in the off-line task but normal performance in the on-line task using the same sentences. Performance on the off-line task correlated with independent measures of verbal working memory. These data are used to argue that sentence comprehension impairments are related to verbal working memory deficits in AD. |
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