| Abstract: | Aggressive biting of an inanimate target by mice was studied. Males attacked the bite-target more frequently than females, but this difference disappeared after castration when the response rate of the males approached that of the females. Ovariectomizing the females had little effect on their bite-attack frequencies. Subsequent androgen injections restored the biting-attack frequency of the castrated males to preoperative levels but had little effect on the intact males. Estrogen had little effect on the response frequency of the females, whereas androgen produced a slight increase in their bite-attack frequency. Results indicate that androgen is critical for the maintenance of this aggressive response and that the single subject paradigm utilized in this study was a sensitive measure of aggressive tendencies in mice. |
