Cholesterol and aggression

Best known for its etiological influence in the cardiovascular disease process, serum cholesterol also plays a role in numerous psychological processes, including affect, cognition, and overt behavior. Prominently, it is related to aggression in humans and other primates. Lipid studies of violent offenders, primary prevention trials of cholesterol reduction, and experimental dietary manipulations in nonhuman primates all point to a significant negative association between cholesterol and physical aggression. By contrast, a positive though inconsistent association between serum cholesterol elevations and verbal aggression (e.g., hostility) has been reported in many studies and often ascribed to a neurophysiological response to acute or chronic stress. We review the numerous studies that have examined the link between serum cholesterol, verbal and physical aggression, and integrate current findings.