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认知行为治疗的生物学机制
引用本文:高见,王鹏翀,李占江. 认知行为治疗的生物学机制[J]. 心理科学进展, 2019, 27(3): 522-532. DOI: 10.3724/SP.J.1042.2019.00522
作者姓名:高见  王鹏翀  李占江
作者单位:首都医科大学附属北京安定医院/临床心理学系, 国家精神心理疾病临床医学研究中心, 北京市精神疾病诊断与治疗重点实验室, 北京 100088
基金项目:国家自然科学基金面上项目(81271493);首都卫生发展科研专项项目首发(2016-1-2121)
摘    要:现阶段认知行为治疗的生物学机制尚不明确。本文将从脑功能、神经电生理、神经内分泌与免疫以及遗传与表观遗传这四个方面对认知行为治疗的生物学机制进行讨论, 综合心理、生理和遗传三方面的结果, 从微观、中间和宏观多层面提出了认知行为治疗生物学机制的整合模型。并进一步对目前研究的局限性进行了讨论, 为未来探究认知行为治疗的生物学机制提供了新的方向。

关 键 词:认知行为治疗  事件相关电位  神经内分泌  促炎细胞因子  表观遗传  
收稿时间:2017-12-13

The biological mechanism of cognitive behavioral therapy
GAO Jian,WANG Pengchong,LI Zhanjiang. The biological mechanism of cognitive behavioral therapy[J]. Advances In Psychological Science, 2019, 27(3): 522-532. DOI: 10.3724/SP.J.1042.2019.00522
Authors:GAO Jian  WANG Pengchong  LI Zhanjiang
Affiliation:The China Clinical Research Center for Mental Disorder & Beijing Key Laboratory of Diagnosis and Treatment of Mental Disorders, Beijing Anding Hospital, Capital Medical University, Beijing 100088, China
Abstract:At present the biological mechanisms of cognitive behavioral therapy are not clear and need to explore. This paper will discuss the biological mechanisms of cognitive behavioral therapy from four aspects of brain function, neuroelectrophysiology, neuroendocrine system and immunity, heredity and epigenetics, involving multiple mechanisms. Combining the results of psychology, physiology and heredity, this paper proposes that the biological integration mechanism of cognitive behavioral therapy is a multi-disciplinary integration model which develops from micro, middle and macro levels. Moreover, the limitations of the present results of previous studies are also discussed and a new direction for exploring the biological mechanism of cognitive behavioral therapy are provided. We intend to establish a foundation for promoting the development of cognitive behavioral therapy.
Keywords:CBT  event-related potentials  neuroendocrine system  pro-inflammatory cytokines  epigenetics  
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