基因-脑-行为视角下的自伤行为产生机制

自伤是遗传与环境共同作用的结果。目前对于自伤行为的探讨已深入到基因及神经系统层面,基因-脑-行为的综合视角为客观揭示自伤产生机制提供了一条有效途径。本文将在已有研究的基础上,结合分子遗传学和神经生物学的最新成果,对自伤候选基因多态性及其可能的脑机制进行系统阐述,并提出今后应在基因多态性的交互作用及其脑机制、积极环境下自伤行为研究、自伤青少年的追踪研究以及自伤行为的系统性探讨等方面进一步深化。

The Mechanism of Non-suicidal Self-injury: From the Perspective of Gene-brain-behavior Framework

Non-suicidal self-injury (NSSI) refers to the behavior that intentionally and repeatedly harms his or her own body tissues without suicide intention. Its universality and serious consequences have aroused researchers' great attention. NSSI is the result of genetic and environmental interaction. The discussion of individual genetic traits has reached the genetic and neurological level now; the gene-brain-behavioral research paradigm provides an effective way to explore the mechanism of NSSI. In this paper, based on the existing NSSI studies and relevant research results, the polymorphism of candidate genes of NSSZ and its possible brain mechanism were comprehensively elaborated. Future research could focus on the issues of polygene-environment interaction, gene-brain-NSSZ in positive environment,the longitudinal study paradigm among adolescents, and further systematic research.