遗忘的药物——呋喃妥因在尿路感染中的应用

随着抗生素的不断发明和应用,目前临床中已经发生很多耐药菌的尿路感染,极大地增加了医疗负担。呋喃妥因虽已使用50多年,但很少耐药菌株,费用低廉,临床仍有广阔的应用前景。本文复习呋喃妥因的相关指南推荐、作用机制、体内代谢、临床抗菌特点和副作用等,希望引起对这个被临床逐渐遗忘的药物重视。

One Forgotten Drug Nitrofurantoin Applied in Urinary Tract Infection

With the antibiotics constantly invented and widely prescribed, antibiotic resistance among bacteria that cause uri- nary tract infections has increased steadily in recent decades, which increases the burden on health care greatly. Nitro- furantoin is a less resistant and relatively inexpensive antibiotic that is used extensively for urinary tract infections. This paper tries to give this drug more attention by reviewing the guideline recommend and pharmacology mechanism and metab- olism and antibacterial spectrum and side effect.