Metabolic Syndrome and Cognitive Function in Healthy Middle-Aged and Older Adults without Diabetes

ABSTRACT

Objective: Few studies have addressed whether the metabolic syndrome (MetS) and its individual components are associated with cognitive function in middle-aged and older populations, as well as whether specific areas of cognition are more affected than others. We examined the cross-sectional association between MetS and six areas of cognitive function in healthy cognitively intact adults without diabetes (n?=?853, mean age 61 years) randomized in two intervention trials. Methods: The National Cholesterol Education Program (NCEP) criteria were used to identify subjects with MetS. Cognitive function was assessed with a neuropsychological battery. A principal components analysis was used to extract five uncorrelated factors interpreted to represent five areas of cognition, and a measure of global cognition was calculated. Results: MetS was weakly but non-significantly associated with lower verbal learning (β?=??.14 [SE(β)?=?0.09], p?=?.15). As the number of MetS criteria increased, scores on global cognition (p trend?=?.01), verbal learning (p trend?=?.06) and semantic memory (p trend?=?.04) decreased. Hypertension was the only MetS risk factor that was independently correlated with lower verbal learning (β?=??.17 [SE(β) =?0.08], p?=?.04), semantic memory (β?=??.26 [SE(β)?=?0.08], p?=?.001) and global cognition (β?=??.15 [SE(β)?=?0.07], p?=?.04). Conclusion: This study adds to the evidence of an association between MetS and lower cognitive function among healthy middle-aged and older adults without CVD and diabetes, as well as confirms the correlation between hypertension and lower cognition.