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Framingham vascular age is associated with worse cognitive performance in the middle-aged and elderly
Authors:Abdul Badran  Matthew J. Hollocks  Rebecca L. Brookes  Robin G. Morris  Hugh S. Markus
Affiliation:1. Churchill College, University of Cambridge, Cambridge, UK;2. Department of Clinical Neurosciences, University of Cambridge, Addenbrookes Biomedical Campus, Cambridge, UK;3. Department of Psychology, Institute of Psychiatry, King’s College London, London, UK
Abstract:“Normal” age-related cognitive decline has been associated with cardiovascular risk factors. Framingham Vascular Age is age-normed cardiovascular risk which may help communicate risk to patients and identify those at relatively higher risk. We aim to assess the association between Framingham Vascular Age and cognition. 346 “healthy” participants (57±10 years) without neuropsychiatric disorders or clinical manifestations of cardiovascular disease were studied. Cognition was evaluated using the Brief Memory and Executive Test and Framingham Vascular Age was calculated. The association between Framingham Vascular Age and cognitive performance was determined through General Linear Models to control for covariates. Framingham Vascular age was associated with poorer Memory and Executive Function/Processing Speed indices (p= 0.019 and p<0.001, respectively). We conclude Framingham Vascular Age is associated with worse Executive Function/Processing Speed and Memory. Vascular Age may help identify patients at higher risk of age-related cognitive decline with implications for communicating the morbidity associated with cardiovascular risk.
Keywords:Age-related cognitive decline  vascular age  brief memory and executive test  Framingham  screening
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