The primate working memory networks |
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Authors: | Email author" target="_blank">Christos?ConstantinidisEmail author Emmanuel?Procyk |
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Institution: | Department of Neurobiology and Anatomy, Wake Forest University School of Medicine, Winston-Salem, NC 27157-1010, USA. cconstan@wfubmc.edu |
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Abstract: | Working memory has long been associated with the prefrontal cortex, since damage to this brain area can critically impair
the ability to maintain and update mnemonic information. Anatomical and physiological evidence suggests, however, that the
prefrontal cortex is part of a broader network of interconnected brain areas involved in working memory. These include the
parietal and temporal association areas of the cerebral cortex, cingulate and limbic areas, and subcortical structures such
as the mediodorsal thalamus and the basal ganglia. Neurophysiological studies in primates confirm the involvement of areas
beyond the frontal lobe and illustrate that working memory involves parallel, distributed neuronal networks. In this article,
we review the current understanding of the anatomical organization of networks mediating working memory and the neural correlates
of memory manifested in each of their nodes. The neural mechanisms of memory maintenance and the integrative role of the prefrontal
cortex are also discussed. |
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Keywords: | |
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