Hippocampal lesion effects on occasion setting by contextual and discrete stimuli |
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| Authors: | Taejib Yoon Lauren K. Graham Jeansok J. Kim |
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| Affiliation: | 1. Department of Psychology, University of Washington, Seattle, WA 98195-1525, United States;2. Program in Neurobiology & Behavior, University of Washington, Seattle, WA 98195-1525, United States;1. Shanghai Institute for Pediatric Research, Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, China;2. Department of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Jianshe East Road No. 1, Zhengzhou 450052, China;3. Hematology Research and Advanced Diagnostics Laboratories, 510 Research Institute, Children’s Hospital of Orange County, 1201 W. La Veta Avenue, Orange, CA 92868, United States;1. National Perinatal Epidemiology and Statistics Unit, Center for Big Data Research in Health, School of Women''s and Children''s Health, Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia;2. Department of Obstetrics and Gynaecology, University of Auckland, Auckland, New Zealand;3. Faculty of Health, University of Technology, Sydney, Sydney, New South Wales, Australia;1. Shanghai Institute for Pediatric Research, Xinhua Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Kongjiang Road 1665, Shanghai 200092, P.R.China;2. Immune/Inflammatory Disease Research Group, Children’s Hospital of Orange County, Research Institute, 455 So. Main Street, Orange, CA 92868, USA |
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| Abstract: | Three experiments examined the role of the dorsal hippocampus (dHIPP) in occasion setting with diffuse contextual and discrete light stimuli serving as occasion setters in classical fear conditioning with rats. Both sham-operated and dHIPP-lesioned animals readily learned a L→T+, T? serial feature-positive discrimination in which a light (L) “set the occasion” for reinforcement of a tone (T+). dHIPP-lesioned animals were deficient, however, in acquiring a similar discrimination in which different contexts (A and B) served as occasion setters, i.e., A(T+) and B(T?). The lesioned animals also failed to discriminate between a context in which a tone had been partially reinforced and a context in which no conditioning had taken place, whereas sham-operated animals froze more to the tone in the conditioned context than in the novel context. Collectively, the data indicate that the dorsal hippocampus is important in processing information about the signaling value of contextual, but not discrete, stimuli. |
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