Neurobehavioral effects of caffeine on the neonate |
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| Affiliation: | 1. Division of Neurology, The University of British Columbia, Vancouver, British Columbia, V6T 2B5, Canada;2. Vancouver General Hospital Epilepsy Program, Gordon and Leslie Diamond Health Care Centre, 8257 – 2775 Laurel Street, Vancouver, British Columbia, V5Z 1M9, Canada;3. University of British Columbia Neuropsychiatry Program, Detwiller Pavilion, UBC Hospital, 2255 Wesbrook Mall, Vancouver, British Columbia, V6T 2A1, Canada;1. The Arthritis Foundation, 1355 Peachtree St NE, Suite 600, Atlanta, GA 30309, USA;2. US Food and Drug Administration, Silver Spring, MD, USA;3. University of Michigan, Ann Arbor, MI, USA;4. University of Leeds, Leeds, UK;5. Boston University School of Medicine, Boston, MA, USA;6. University of Washington, Seattle, WA, USA;7. University of Maryland School of Medicine, Baltimore, MD, USA;8. Duke University School of Medicine, Durham, NC, USA;9. Cleveland Clinic, Cleveland, OH, USA;10. University of California San Francisco, San Francisco, CA, USA;11. Tufts-New England Medical Center, Boston, MA, USA;12. University of Oulu, Oulu, Finland;13. SDG LLC, Cambridge, MA, USA |
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| Abstract: | This study examined the behavioral effects of caffeine, measured in cord blood and saliva, on infant behavior. In order to examine these effects, 40 full-term, healthy, vaginally delivered, breast-fed neonates and their healthy, nonsmoking mothers were studied. A nutritional questionnaire was developed and given to each participating mother to determine her approximate caffeine intake during the last three days before delivery. For each infant subject, cord blood samples from delivery and saliva samples taken on the day of behavioral testing were assayed for caffeine. Statistical analyses revealed a significant effect of caffeine level on certain interactive behaviors in response to stimulation but little or no observed effect upon spontaneous sleep states. |
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