Factors Associated with Interest in Gene-Panel Testing and Risk Communication Preferences in Women from BRCA1/2 Negative Families |
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Authors: | Kristina G. Flores Laurie E. Steffen Christopher J. McLouth Belinda E. Vicuña Amanda Gammon Wendy Kohlmann Lucretia Vigil Zoneddy R. Dayao Melanie E. Royce Anita Y. Kinney |
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Affiliation: | 1.University of New Mexico Comprehensive Cancer Center, University of New Mexico,Albuquerque,USA;2.Department of Psychology,University of New Mexico,Albuquerque,USA;3.Huntsman Cancer Institute,University of Utah,Salt Lake City,USA;4.Department of Internal Medicine,University of New Mexico,Albuquerque,USA |
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Abstract: | Scientific advances have allowed the development of multiplex gene-panels to assess many genes simultaneously in women who have tested negative for BRCA1/2. We examined correlates of interest in testing for genes that confer modest and moderate breast cancer risk and risk communication preferences for women from BRCA negative families. Female first-degree relatives of breast cancer patients who tested negative for BRCA1/2 mutations (N = 149) completed a survey assessing multiplex genetic testing interest and risk communication preferences. Interest in testing was high (70 %) and even higher if results could guide risk-reducing behavior changes such as taking medications (79 %). Participants preferred to receive genomic risk communications from a variety of sources including: primary care physicians (83 %), genetic counselors (78 %), printed materials (71 %) and the web (60 %). Factors that were independently associated with testing interest were: perceived lifetime risk of developing cancer (odds ratio (OR) = 1.67: 95 % confidence interval (CI) 1.06–2.65) and high cancer worry (OR = 3.12: CI 1.28–7.60). Findings suggest that women from BRCA1/2 negative families are a unique population and may be primed for behavior change. Findings also provide guidance for clinicians who can help develop genomic risk communications, promote informed decision making and customize behavioral interventions. |
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