| 脂联素基因多态性与原发性高血压研究进展 |
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| 引用本文： | 唐晓明,李洁琪. 脂联素基因多态性与原发性高血压研究进展[J]. 医学与哲学(人文社会医学版), 2008, 29(5): 58-60 |
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| 作者姓名： | 唐晓明 李洁琪 |
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| 作者单位： | [1]核工业成都416医院心内科,四川成都610051 [2]贵阳医学院附属医院心内科,贵州贵阳550044 |
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| 摘 要： | 脂联素是脂肪细胞特异性细胞因子，与糖、脂代谢、胰岛素抵抗密切相关，具有抗炎、抗动脉粥样硬化特性。脂联素基因序列中存在相当数量的等位基因单核苷酸多态性（SNPs），＋45T／G、＋164I／T和＋276G／TSNPs发生频率在原发性高血压（EH）中增高，直接影响脂联素血浆浓度。脂联素基因SNPs是EH的一个新易感因素。
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| 关 键 词： | 脂联素 基因多态性 原发性高血压 |
The Relationship Between Adiponectin Gene Polymorphismand and Essential Hypertension |
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| Affiliation: | TANG Xiao-ming, LI Jie-qi( The Nuclear-industry Chengdu 416 Hospital , Chengdu 610051 ,China ) |
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| Abstract: | Adiponectin, an adipocyte--secreted protein, is known to have glycometablolism, lipid metabolism, insulin resistance anti--atherogenic, anti--inflammatory and diabetic properties. Adiponectin gene （APM1） have more than 10 single nucleotide polymorphisms. ＋45T/G, ＋ 164I/T and ＋276G/T SNPs have been frequently referred to be in association with EH and plsama adiponectin concentration. Mutation in APM 1 gene was susceptibility of gene for EH. |
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| Keywords: | adiponectin gene polymorphism essential hypertension |
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