原发性子宫颈腺癌和子宫内膜腺癌的鉴别诊断

采用组织阵列和免疫组化技术对39例子宫颈腺癌和20例子宫内膜腺癌进行Vimentin，CEA，ER，PR，CKs（7，19和20），MUC antigen（1和5）和CD10抗体的检测。93％的黏液性宫颈腺癌表现为Vimentin和ER阴性，96％为PR阴性；20例子宫内膜样子宫内膜腺癌中，Vimentin阳性占90％，ER阳性占80％，PR阳性高达96％。CEA阳性率在宫颈癌中为81％，在子宫内膜样子宫内膜腺癌中有15％为灶状阳性表达。CD10在85％的子宫内膜腺癌组织的间质细胞中为阳性表达，仅有15％的宫颈腺癌表现为间质细胞染色阳性。MUC和CKs系列的蛋白表达未发现显著差异。

Introduction of Organ Donation Assessment Methods Abroad

Tissue microarray from the paraffin--embedded tissues and immunohistochemistry were used in the detection of protein expressions for vimentin, CEA, ER, PR, CKs （7, 19 and 201 , MUC antigen （1 and 5） and CD10. The result indicated most of mucinous endocervical adenocarcinomas （ECCAs） were vimentin- negative （ 93 % ）, ER- negative （ 93% ） , PR- negative （ 96 % ） ; and most of 20 endometrial adenocarcinomas （EMCAs） were vimentin- positive （ 90 % ）, ER- positive （80%） and PR-positive （95%）. The great majority of ECCAs were CEA-positive （81%）, whereas focal positive in EMCAs （15%）. However, all EMCAs and ECCAs were positive for CK7 and 19, whereas CK 20 were negative in all EMCAs, but positive in 12 of 39（30%） ECCAs. In addition, CD10-positive stroma was seen in the majority of EMCAs （85%） , but only in minority of ECCAs （15%）. MUC1 and MUC5 expressions were seen both EMCAs and ECCAs （90 % and 45% versus 61% and 82%）.