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Severe psychosis and the adrenal androgens
Authors:James S. Howard M.D.
Affiliation:1. Dept. of Health, P.O. Box 11867, 93775, Fresno, CA
Abstract:Past literature suggests a link between certain psychotic states and adrenal androgen production, including Dehydroepiandrosterone (DHEA). A group of severely psychotic androgenized females, refractory to substantial amounts of neuroleptics, has been identified for whom endocrine testing revealed abnormaly high levels of DHEA. A similar group has been identified among the severely psychotic male population. Improvement in psychosis appears to occur as DHEA returns to its normal range using standard low dose Dexamethasone suppression.
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