|
|||||
|
|
Collaboration of Colorado Cancer Genetic Counselors to Integrate Next Generation Sequencing Panels into Clinical Practice |
|
| Authors: | K. Wolfe Schneider A. Anguiano L. Axell C. Barth K. Crow M. Gilstrap B. A. Hamlington S. Lesh L. Mullineaux A. Kulchak Rahm E. Strait M. Freivogel |
| Affiliation: | 1. Department of Pediatrics, University of Colorado, Aurora, CO, USA 13. Center for Cancer and Blood Disorders, Children’s Hospital Colorado, 13123 E. 16th Ave, B115, Aurora, CO, 80045, USA 2. Risk Assessment and Prevention Program, Invision Sally Jobe, Greenwood Village, CO, USA 3. Comprehensive Cancer Center, University of Colorado, Aurora, CO, USA 4. Regional Cancer Center, St. Mary’s Hospital, Grand Junction, CO, USA 5. Hereditary Cancer Service, Dorcy Cancer Center, St. Mary-Corwin Medical Center, Pueblo, CO, USA 6. Genetic Counseling Clinic, Porter Adventist Hospital, Denver, CO, USA 7. Rocky Mountain Cancer Centers, US Oncology, Denver, CO, USA 8. Genetic Counseling Services, Exempla Saint Joseph Comprehensive Cancer Center, Denver, CO, USA 9. Genetic Counseling Services, Exempla Good Sam Medical Center, Lafayette, CO, USA 10. Mile High Oncology, Littleton Adventist Hospital, Littleton, CO, USA 11. Adult Genetic Services, Kaiser Permanente, Denver, CO, USA 12. Hereditary Cancer Service, Penrose Cancer Center, Colorado Springs, CO, USA |
| Abstract: | The recent introduction of clinically available next generation sequencing (NGS) cancer panels has presented new challenges for genetic counselors. Determining which patients are appropriate for NGS panel testing is complex. Due to the large number of genes included in the NGS panels, thorough and appropriate pre-test counseling and interpretation of NGS results can be a time-consuming and difficult process. Many of the genes associated with increased cancer risk lack published clinical management guidelines and estimates of cancer risk for individuals with deleterious mutations. In order to efficiently and effectively review the clinical utility of NGS panels, Colorado cancer genetic counselors formed a working group to gain a better understanding of the genes included in NGS cancer panels. This publication reports on the approach of this group, the process used to evaluate a selected NGS panel, future directions for this collaboration, and ideas for other genetic counselors to form similar groups to efficiently evaluate new technologies and improve practice. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |