| 精神分裂症的潜伏抑制动物模型 |
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| 引用本文： | 邵枫,王玮文,刘美,金暕. 精神分裂症的潜伏抑制动物模型[J]. 心理科学进展, 2008, 16(3): 392-398. DOI: |
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| 作者姓名： | 邵枫 王玮文 刘美 金暕 |
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| 作者单位： | 北京大学心理学系，北京 100871 |
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| 基金项目： | 国家自然科学基金 , 中国科学院方向性项目 , 国家重点基础研究发展计划(973计划) |
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| 摘 要： | 精神分裂症动物模型的建立，是当前研究精神分裂症的神经生物学机制以及开发新的抗精神病药物的一个重要课题。文章系统地阐述了以潜伏抑制为行为模式的精神分裂症动物模型的理论以及神经机制，并重点介绍了精神分裂症的潜伏抑制动物模型的建立方法，包括（1）调节某些与精神分裂症相关的中枢神经递质的传递活动；（2）对与精神分裂症有关的中脑-伏隔核神经环路进行结构损伤或药物性干预；（3）在发育早期给予免疫刺激或环境应激
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| 关 键 词： | 精神分裂症动物模型，潜伏抑制，中脑-伏隔核神经环路 |
| 收稿时间： | 2007-12-31 |
| 修稿时间： | 2007-12-31 |
Latent Inhibition as an Animal Model of Schizophrenia |
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| SHAO Feng,WANG Wei-Wen,LIU Mei,JIN Jian. Latent Inhibition as an Animal Model of Schizophrenia[J]. Advances In Psychological Science, 2008, 16(3): 392-398. DOI: |
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| Authors: | SHAO Feng WANG Wei-Wen LIU Mei JIN Jian |
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| Affiliation: | Department of Psychology, Peking University, Beijing 100871, China |
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| Abstract: | Abstract: Establishment of animal models of schizophrenia was critical for both understanding the mechanisms underlying this severe mental disease and developing new antipsychotics. This review thoroughly described the theory and neural substrate of the latent inhibition model of schizophrenia. The main methods for inducing latent inhibition abnormality in experimental animals included (1) modulations of neurotransmissions that were closely associated with schizophrenia, (2) focal lesions or pharmacological manipulations of brain structures in the meso-nucleus accumbens neural circuit, and (3) immune stimulus or isolated stress during early development. |
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| Keywords: | animal model of schizophrenia latent inhibition meso-nucleus accumbens neural circuit |
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