原发性肾病综合征合并甲状腺功能异常患者临床资料分析

分析原发性肾病综合征合并甲状腺功能异常患者的临床特征，探讨其，I盏床意义。对37例原发性肾病综合征合并甲状腺功能异常患者的，陆床资料进行回顾性分析，治疗前检测甲状腺过氧化物酶抗体（Anti～TPO）、甲状腺球蛋白抗体（Anti—TG），并分别于治疗前后检测血清游离T3（FT3）、血清游离甲状腺激素（FT4）、促甲状腺激...

Analysis of Clinical Data in Primary Nephrotic Syndrome Accompanied with Thyroid Dysfunction

To investigate the clinical significance , clinical features of patients with primary nephrotic syndrome accompanied with thyroid dysfunction were analysed. Thirty seven patients with primary nephrotic syndrome accompanied with thyroid dysfunction were se- lected in this retrospective study. Levels of FT3, FT4 ,TSH, 24h proteinuria quantitative, serum albumin, total cholesterol, triglyceride were detected before and after treatment , while Anti--TPO and Anti--TG were detected before treatment. Decreased level of FT3 was detected in 19 cases（51.4~）, decreased level of FT4 was detected in 7 cases （18. 9~） and decreased level of FT4 accompanied with increased levels of TSH and Anti--TPO occured in 2 cases（ 5.4 %）. None of the patients presented clinical manifestations of hypothyroidism. Serum level of FT3 was positively correlated with serum albumin but negatively correlated with urinary protein. No correlation was found between serum thyroid hormone levels and total cholesterol,triglyceride. Patients with primary nephrotic syndrome may be accompanied with abnormal FT3 , FT4 and TSH , which may be improved with relief of the disease. Measurement of serum thyroid hormone in nephrotic syndrome patients might be a predictor of the disease severity and prognosis.