| Affiliation: | 1. EPIC Center, Montreal Heart Institute, University of Montreal, Montreal, Quebec, Canada;2. Wisconsin Alzheimer’s Institute, University of Wisconsin, Madison, Wisconsin, USA;3. Wisconsin Alzheimer’s Institute, University of Wisconsin, Madison, Wisconsin, USA Geriatric Research Education and Clinical Center, Madison, Wisconsin, USA;4. Faculty of Psychology, Liverpool John Moores University, Liverpool, UK |
| Abstract: | The temporal contiguity effect is the tendency to form associations between items presented in nearby study positions. In the present study, we explored whether temporal contiguity predicted conversion to cognitively unimpaired-declining (CUD) status from a baseline of unimpaired older adults. Data from 419 participants were drawn from the Wisconsin Registry of Alzheimer’s Prevention (WRAP) data set and analysed with binary logistic regressions. Temporal contiguity was calculated using the Rey Auditory Verbal Learning Test. Other predictors included age, years of education, sex, APOE-ε4 status, and other measures of memory recall. Lower temporal contiguity predicted conversion to CUD after accounting for covariates. These findings support the hypothesis that temporal organization in memory is related to cognitive decline and suggest that temporal contiguity may be used for studies of early detection. |
