| 胰岛素样生长因子结合蛋白3mRNA在肾癌中的表达 |
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| 引用本文： | 任巨超,宋培培,闫磊,焦伟,李大伟,徐忠华,刘照旭,刘海南. 胰岛素样生长因子结合蛋白3mRNA在肾癌中的表达[J]. 医学与哲学(人文社会医学版), 2009, 30(2): 37-38,41 |
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| 作者姓名： | 任巨超 宋培培 闫磊 焦伟 李大伟 徐忠华 刘照旭 刘海南 |
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| 作者单位： | [1]山东大学齐鲁医院泌尿外科,山东济南250012 [2]山东大学附属省立医院,山东济南250021 |
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| 摘 要： | 为探讨胰岛素样生长因子结合蛋白3（IGFBP-3）mRNA在肾癌（RCC）中的表达，采用半定量RT-PCR方法进行检测，检测56例RCC组织标本及56例癌旁组织标本中IGFBP-3的表达。结果显示RCC与癌旁组织之间IGFBP-3表达差异有显著性（P〈0.05），IGFBP-3在透明细胞癌的强阳性表达，高于其他病理类型（P均〈0.05），并与病理分级相关。因此，IGFBP-3在RCC组织中的表达具有显著性，其在肾透明细胞癌中的强阳性表达具有特异性。
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| 关 键 词： | 肾细胞癌 胰岛素样生长因子结合蛋白3 逆转录-聚合酶链反应 |
mRNA Expression of Insulin-Like Growth Factor Binding Protein 3 in Clear Cell Renal Cell Carcinoma |
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| Affiliation: | REN Ju-chao,SONG Pei-pei ,YAN Lei ,et al.( Department of Urology ,Qilu Hospital of Shandong University, Ji＇nan 250012, China) |
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| Abstract: | To detect the expression of insulin-like growth factor binding protein 3（IGFBP-3）mRNA in renal cell carcinoma（RCC）. semi-quantitive RT-PCR was applied to detect the expressions of IGFBP-3 in 56 samples of RCC tissue and 56 samples of the adjacent-tumor renal tissue. The expression of IGFBP-3 in clear cell RCC tissue were significantly higher than the adjacent-tumor renal tissue（P〈0.05）. The increasing positive IGFBP-3 expression in clear cell RCC was significantly higher than in other RCC（all P〈0.05）, and it is associated with patho-grade. Therefore, IGFBP-3 is over-expressed in RCC tissue. The increasing positive IGFBP-3 expression is specific in clear cell RCC. |
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