The role of the dorsal CA1 and ventral CA1 in memory for the temporal order of a sequence of odors |
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| Authors: | Raymond P. Kesner Michael R. Hunsaker Warren Ziegler |
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| Affiliation: | 1. Department of Psychology, University of Utah, Salt Lake City, UT, USA;2. Program in Neuroscience, University of California, Davis, CA, USA;1. Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, PR China;2. University of Chinese Academy of Sciences, Beijing, PR China;3. Department of Life Sciences, Binzhou University, Binzhou, Shandong Province, PR China;4. School of Education Science, Henan University, Kaifeng, Henan Province, PR China;1. RIKEN-MIT Center for Neural Circuit Genetics at the Picower Institute for Learning and Memory, Department of Biology and Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. RIKEN BioResource Center, 3-1-1 Koyadai, Ibaraki 305-0074, Japan;3. Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;4. RIKEN Brain Science Institute, 2-1 Hirosawa, Wako-shi, Saitama 351-0198, Japan;1. Departments of Neuroscience, Psychiatry & Pharmacology, Columbia University, New York, NY, USA;2. Division of Integrative Neuroscience, Department of Psychiatry, New York State Psychiatric Institute, New York, NY, USA;3. Department of Psychiatry, University of California, San Francisco, San Francisco, CA, USA;4. Center for the Neural Basis of Cognition and Machine Learning Department, Carnegie Mellon University, Pittsburgh, PA, USA;5. Departments of Statistics and Neuroscience, Grossman Center for the Statistics of Mind, Center for Theoretical Neuroscience, Kavli Institute for Brain Science, and NeuroTechnology Center, Columbia University, New York, NY, USA;6. Department of Psychiatry and Behavioral Sciences, Stanford University, Stanford, CA, USA;7. Department of Pharmacology, University of Washington, Seattle, WA 98105, USA;8. Department of Psychiatry and Behavioral Sciences, University of Washington, Seattle, WA 98105, USA;9. Neuroscience Graduate Program, University of California, San Francisco, San Francisco, CA, USA;10. Weill Institute for Neurosciences, University of California, San Francisco, San Francisco, CA, USA;11. Kavli Institute for Fundamental Neuroscience, University of California, San Francisco, San Francisco, CA, USA;12. Center for Integrative Neuroscience, University of California, San Francisco, San Francisco, CA, USA;1. Neurobiology Section and Center for Neural Circuits and Behavior, Division of Biological Sciences, University of California, San Diego, La Jolla, CA 92093, USA;2. Canadian Centre for Behavioural Neuroscience, Department of Neuroscience, University of Lethbridge, Lethbridge, AB T1K 3M4, Canada;3. Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92093, USA;1. Department of Psychology (Scarborough), University of Toronto, ON M1C 1A4, Canada;2. Rotman Research Institute, Baycrest Centre, Toronto, ON M6A 2E1, Canada;3. Department of Cell and Systems Biology, University of Toronto, Toronto, ON M5S 3G5, Canada |
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| Abstract: | Memory for the temporal order of a sequence of odors was assessed in male rats. A sequence of five odors mixed in sand was presented in digging cups one at a time to each rat in a sequence that varied on each trial. A reward was buried in each cup. Following the fifth odor, two of the previous five odors were presented simultaneously and the rat needed to choose the odor that occurred earliest in the sequence to receive a reward. Temporal separations of 1, 2, or 3 were used which represented the number of odors that occurred between the two odors in the sequence. Once pre-operative criterion was reached, rats received a control, dorsal CA1 (dCA1), or ventral CA1 (vCA1) lesion and were retested on the task. On post-operative trials, only the vCA1 group was impaired relative to both control and dCA1 groups. All groups of rats could discriminate between the odors. The data suggest that the vCA1, but not dorsal CA1, is involved in separating sensory events (odors) in time so that one odor can be remembered separate from another odor. |
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