Vasopressin/oxytocin-related peptides influence long-term memory of a passive avoidance task in the cuttlefish,Sepia officinalis |
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| Authors: | Isabelle Bardou Jérôme Leprince Raymond Chichery Hubert Vaudry Véronique Agin |
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| Affiliation: | 1. GMPc, Groupe Mémoire et Plasticité Comportementale, EA 4259, University of Caen Basse-Normandie, 14032 Caen Cedex, France;2. INSERM U413, Laboratory of Cellular and Molecular Neuroendocrinology, European Institute for Peptide Research (IFRMP 23), Regional Platform for Cell Imaging (PRIMACEN), University of Rouen, 76821 Mont-Saint-Aignan, France;3. INSERM U919, SP2U, Serine Proteases and Pathophysiology of the Neurovascular Unit, UMR CNRS 6232 CI-NAPS, Centre for Imaging-Neuroscience and Applications to Pathologies, GIP CYCERON/University of Caen Basse-Normandie, 14074 Caen Cedex, France;1. National Engineering Research Center of Marine Facilities for Aquaculture, School of Marine Science and Technology, Zhejiang Ocean University, Zhoushan 316022, PR China;2. Key Laboratory of Sustainable Development of Marine Fisheries, Minister of Agriculture, Yellow Sea Fisheries Research Institute, Chinese Academy of Fishery Science, Qingdao 266071, PR China;1. Normandie Université, CS F-14032 Caen, France;2. GMPc (Groupe Mémoire et Plasticité comportementale), EA 4259, Campus Horowitz, Université de Caen Normandie, Esplanade de la Paix, CS F-14032 Caen cedex, France;3. EPOC (Environnements et Paléoenvironnements Océaniques et Continentaux), UMR 5805 CNRS, Laboratoire de Physico- et Toxico-Chimie de l’Environnement (LPTC), 351 crs de la Libération, F-33405 Talence, France;4. Faculty of Agricultural and Environmental Sciences, McGill University, Montreal, QC, H9X 2T9, Canada |
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| Abstract: | The vasopressin (VP)/oxytocin (OT)-related peptides constitute a large superfamily found in a wide range of both vertebrate and invertebrate species. While intensive literature reports that these neuropeptides influence behavior, especially learning and memory, in numerous species from diverse vertebrate groups, their roles in behavioral regulation have never been studied in invertebrates. Here, we investigated the role of two VP/OT superfamily peptides, octopressin (OP) and cephalotocin (CT), on long-term memory (LTM) formation of a passive avoidance task in a cephalopod mollusc, the cuttlefish, Sepia officinalis. Subadult cuttlefish were intravenously injected, in a dose range of 3–60 μg/kg, 1 h after the training phase (consolidation design); retention performance was tested 24 h post-training. We found that administration of OP at low dose (3 μg/kg) enhanced LTM, whereas a dose of 60 μg/kg attenuated it. No effect of OP on LTM was observed for the 15 μg/kg dose. Conversely, an enhancement of retention performance was observed at all doses of CT tested. This study is the first to demonstrate the behavioral effects of VP/OT superfamily peptides in an invertebrate species. The valuable role of VP/OT-like peptides on memory processes offers new evolutionary perspectives on peptidergic transmission and neuromodulation. |
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