Temporary inactivation of the dorsal entorhinal cortex impairs acquisition and retrieval of spatial information |
| |
| Authors: | Stephane Gaskin Norman M White |
| |
| Institution: | 1. Center for Studies in Behavioural Neurobiology, Concordia University, Montréal, Quebec, Canada;2. Department of Psychology, McGill University, Montréal, Quebec, Canada;1. Department of Neurology, Charité – Universitätsmedizin Berlin, Berlin, Germany;2. Berlin School of Mind and Brain, Humboldt-Universität, Berlin, Germany;3. Institute of Cognitive Neurology and Dementia Research, Otto-von-Guericke University Magdeburg, Magdeburg, Germany;4. German Center for Neurodegenerative Diseases (DZNE) Site, Magdeburg, Germany;5. Institute of Cognitive Neuroscience, University College London, London, United Kingdom;6. Department of Education and Psychology, Freie Universität Berlin, Berlin, Germany;7. Cluster of Excellence “Languages of Emotion”, Freie Universität Berlin, Berlin, Germany;8. Epilepsy-Center Berlin-Brandenburg, Evangelisches Krankenhaus Königin Elisabeth Herzberge, Berlin, Germany;9. Department of Nephrology and Medical Intensive Care Medicine, Charité – Universitätsmedizin Berlin, Berlin, Germany;1. UCL Institute of Cognitive Neuroscience, and UCL Institute of Neurology, University College London, 17 Queen Square, London WC1N 3AZ, UK |
| |
| Abstract: | We tested the effects of temporary inactivation of the dorsal entorhinal cortex on spatial discrimination using a conditioned cue preference (CCP) paradigm. The three phases of the procedure were: pre-exposure: unreinforced exploration of the center platform and two adjacent arms of an eight-arm radial maze; training: rats were confined to the ends of the two arms on alternate days – one arm always contained food and the other never contained food; testing: unreinforced exploration of the center platform and the two arms. Rats that received bilateral infusions of saline into the dorsal entorhinal cortex before the training trials or before the test trial spent significantly more time in the arm that previously contained food than in the arm that never contained food, demonstrating that they had acquired and were able to express information that discriminated between the two adjacent maze arms. In contrast, rats that received bilateral, intra-entorhinal infusions of muscimol, a gamma-aminobutyric acida (GABAa) agonist, before either training or testing spent equal amounts of time in the two arms, indicating that they failed to acquire and were unable to express this information. Interactions between the entorhinal cortex and hippocampus in the acquisition and expression of the information required for this discrimination are discussed. |
| |
| Keywords: | |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
