Increased stress-induced intra-hippocampus corticosterone rise associated with memory impairments in middle-aged mice |
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| Authors: | C. Tronche C. Piérard M. Coutan F. Chauveau P. Liscia D. Béracochéa |
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| Affiliation: | 1. Institut de Recherche Biomédicale des Armées (IRBA), Département Environnements Opérationnels, BP73, 91223 Brétigny sur Orge-Cedex, France;2. Centre de Neurosciences Intégratives et Cognitives (CNIC), Universités de Bordeaux, UMR-CNRS 5228, Bâtiment Biologie Animale, Avenue des facultés, 33405 Talence Cedex, France;1. Department of General Physics and Spectroscopy, Vilnius University, Sauletekio av. 3-9, Vilnius 10222, Lithuania;2. Interdisciplinary Center for Molecular Materials (ICMM) and Computer-Chemistry-Center (CCC), Friedrich-Alexander-University Erlangen-Nürnberg, Nägelsbachstr. 25, 91052 Erlangen, Germany;3. Institute of Chemistry, University of Bialystok, Hurtowa 1, 15-399 Bialystok, Poland;1. Rudolf Magnus Institute of Neurosciences, Department of Neuroscience and Pharmacology, UMC Utrecht, Utrecht, The Netherlands;2. Arabian Gulf University, College of Medicine and Medical Sciences, Department of Physiology, Manama, Bahrain;1. Laboratorio de Biología Celular, Instituto de Investigaciones Biológicas Clemente Estable, Montevideo, Uruguay;2. Departamento de Fisiología, Facultad de Medicina, Universidad de la República, Montevideo, Uruguay;1. Department of Anatomy, School of Medicine, Konkuk University, 05029 Seoul, Republic of Korea;2. Research Institute of Medical Science, School of Medicine, Konkuk University, 05029 Seoul, Republic of Korea;1. Max Planck Institute of Psychiatry, Kraepelinstrasse 2-10, 80804 Munich, Germany;2. Department of Psychology and Brain Health Research Centre, Box 56, University of Otago, Dunedin 9054, New Zealand;3. Sagol Department of Neurobiology, Faculty of Natural Sciences, University of Haifa, Haifa, Israel;4. Department of Genetics and Molecular Neurobiology, Institute of Biology, Otto-von-Guericke University Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany;5. Center for Behavioral Brain Sciences, 39120 Magdeburg, Germany;6. The Institute for the Study of Affective Neuroscience, University of Haifa, Haifa 31905, Israel |
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| Abstract: | The present study investigates the relationships between hippocampal corticosterone concentrations and memory retrieval performance in stress and non-stress conditions, in both young (6 month-old) and middle-aged (16 month-old) mice. For this purpose, the time-course evolution of stress-induced corticosterone rise in the dorsal hippocampus (dHPC) was investigated in both young and middle-aged mice. In parallel, the evolution of memory retrieval patterns was assessed using a contextual serial discrimination task (CSD). Finally, metyrapone (corticosterone synthesis inhibitor) was administered in order to evaluate the stress-induced impact of corticosterone rise on contextual memory retrieval in middle-aged animals.Results showed that: (i) non-stressed middle-aged mice exhibited a memory retrieval pattern opposite to that of non-stressed young animals, but similar to that of stressed young mice; (ii) the impact of stress on memory performance was transient (90 min) in young, as compared to middle-aged mice (120 min); (iii) dHPC basal (non-stress) corticosterone level was significantly increased by ageing; (iv) acute stress induced a rapid (15 min) and transient (90 min) dHPC corticosterone rise in young mice, while exhibiting greater magnitude and duration (120 min) in middle-aged animals; and (v) both the stress-induced endocrinal and memory effects were blocked by metyrapone in young and middle-aged mice.Finally, to our knowledge, the present work is the first study to directly measure the corticosterone rise in the hippocampus following exposure to stress and to directly correlate the corticosterone changes in the hippocampus with memory performance in both young and middle-aged mice. |
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