The medial prefrontal cortex and memory of cue location in the rat |
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| Authors: | Tim Rawson Michael O’Kane Andrew Talk |
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| Institution: | 1. Powder Metallurgy Research Institute, Central South University, 932, Lushan South Road, Changsha 410083, PR China;2. State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, PR China;3. School of Metallurgy and Environment, Central South University, 932, Lushan South Road, Changsha 410083, PR China;4. Department of Civil Engineering, The University of Hong Kong, Hong Kong;1. Department of Electronics and Instrumentation, Siksha O Anusandhan (deemed to be University), Bhubaneswar, India;2. Multifunctional Materials Laboratory, Department of Physics, Siksha O Anusandhan (deemed to be University), Bhubaneswar, India;1. Department of Physics, National Institute of Technology Mizoram, Aizawl 796012, India;2. Department of Physics, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751030, India;3. Department of Electronics and Instrumentation Engineering, Siksha O Anusandhan (Deemed to be University), Bhubaneswar 751030, India;1. State Key Laboratory of Crystal Materials, Shandong University, 27 Shandanan Road, Jinan, Shandong, 250100, China;2. School of Environment and Energy, Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, South China University of Technology, Guangzhou Higher Education Mega Center, Guangzhou, Guangdong, 510006, China;1. University of Granada, Granada, Spain;2. Simón Bolivar University, Caracas, Venezuela;3. University of York, York, United Kingdom;4. University of New South Wales, Sydney, Australia;1. CSIRO Agriculture and CSIRO Land and Water, Private Bag 10, Clayton South, VIC 3169, Australia;2. CSIRO Agriculture and CSIRO Land and Water, GPO Box 1700, ACT 2601, Australia;3. School of Life and Environmental Sciences, Deakin University, Burwood, VIC 3125, Australia;4. Institute for Applied Ecology, University of Canberra, Bruce, ACT 2617, Australia;5. School of Ecosystem and Forest Sciences, The University of Melbourne, Richmond, VIC 3121, Australia;6. Fenner School of Environment and Society, Australian National University, Canberra, ACT 0200, Australia;7. School of Environmental and Rural Sciences, University of New England, Armidale, NSW 2351, Australia;8. School of Agriculture, Food and Wine, University of Adelaide, Waite Campus, PMB 1 Glen Osmond, SA 5064, Australia;9. Agri-Science Queensland, Department of Agriculture, Fisheries and Forestry, QLD 4556, Australia;10. School of Plant Biology, The University of Western Australia, Crawley, WA 6009, Australia;11. Forest & Nature Lab, Ghent University, BE-9090, Gontrode-Melle, Belgium;12. Department of Environment, Water and Natural Resources, South Australia, Australia |
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| Abstract: | We developed a single-trial cue-location memory task in which rats experienced an auditory cue while exploring an environment. They then recalled and avoided the sound origination point after the cue was paired with shock in a separate context. Subjects with medial prefrontal cortical (mPFC) lesions made no such avoidance response, but both lesioned and control subjects avoided the cue itself when presented at test. A follow up assessment revealed no spatial learning impairment in either group. These findings suggest that the rodent mPFC is required for incidental learning or recollection of the location at which a discrete cue occurred, but is not required for cue recognition or for allocentric spatial memory. |
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