背外侧前额叶对主动遗忘负性社会反馈的作用：针对抑郁症的TMS研究

抑郁症患者的负性心境可能源于其抑制功能障碍。患者在主动遗忘负性材料时无法有效调用背外侧前额叶(the dorsolateral prefrontal cortex, DLPFC)等负责抑制控制的额叶脑网络。同时, 患者对社会信息的加工比对非社会信息的加工存在更明显的认知神经障碍, 很难主动遗忘对自己不利的社会反馈信息。为了提高抑郁症患者对负性社会反馈的主动遗忘能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在左侧(n = 32)或右侧DLPFC (n = 30)被激活后其记忆控制能力的改变。结果表明, 当患者的DLPFC被TMS激活时, 他们对社会拒绝的回忆正确率与健康对照组(n = 31)无差异, 且TMS激活右侧DLPFC还改善了患者对他人的社会态度。本研究是采用TMS提高抑郁症患者主动遗忘能力的首次尝试, 研究结果不但支持了DLPFC与记忆控制功能的因果关系, 还为临床治疗抑郁症、创伤后应激障碍、药物成瘾等患者的记忆控制缺陷提供了明确的神经靶点。     

Changes in anabolic and catabolic activity among women taking part in an alternative labour market programme

Thirty-two female participants in a mobilising labour market programme offering temporary, alternative employment in Sweden were followed longitudinally for one year, including a six month post participation follow-up period. It can be hypothesised that an important aspect of the physiological effects of unemployment is a change in the balance between anabolic and catabolic activities in the body and that re-employment should lead to a shift towards anabolism. An earlier study of a smaller subset of the data, however, including both men and women, showed increased prolactin and decreased dehydroepiadrosterone sulphate (DHEA-s) levels, contrary to the initial hypothesis. In the present analysis, intended to elucidate these results, psychophysiological data were summarised in two indices, one connected with anabolism (made up of testosterone and DHEA-s) and one with catabolism (prolactin, γ-glutamyl transferase, aspartate amino transferase, α levuline amino transferase, and body mass index). In addition, self-rated anxiety, depression, hopelessness and personal control were analysed. The results indicate that the effect of ‘better’ activities within the programme was a temporary increase in anabolism, possibly indicating lower stress levels, and the effect of ‘worse’ activities, on the one hand, a temporary decrease in the catabolic index, probably reflecting repressed alcohol consumption, and, on the other hand, impaired anabolism. There was also a general but transient decrease in depressiveness measured by the Hospital Anxiety and Depression Scale. The results seem to imply that it is difficult to achieve lasting effects through a relatively short participation in a mobilising programme.     

An evaluation of the ability to voluntarily reduce the heart rate after a month of yoga practice

The study aimed at determining whether novices to yoga would be able to reduce their heart rate voluntarily and whether the magnitude of reduction would be more after 30 days of yoga training. Two groups (yoga and control,n=12 each) were assessed on Day 1 and on Day 30. During the intervening 30 days, the yoga group received training in yoga techniques while the control group carried on with their routine. At each assessment the baseline heart rate was recorded for one minute, this was followed by a six-minute period during which participants were asked to attempt to voluntarily reduce their heart rate, using any strategy. Both the baseline heart rate and the lowest heart rate achieved voluntarily during the six-minute period were significantly lower in the yoga group on Day 30 compared to Day 1 by a group average of 10.7 beats per minute (i.e., bpm) and 6.8 bpm, respectively (p<.05, Wilcoxon paired signed ranks test). In contrast, there was no significant change in either the baseline heart rate or the lowest heart rate achieved voluntarily in the control group on Day 30 compared to Day 1. The results suggest that yoga training can enable practitioners to use their own strategies to reduce the heart rate, which has possible therapeutic applications.     

Quadriceps Torque,Peak Variability and Strength Endurance in Patients after Anterior Cruciate Ligament Reconstruction: Impact of Local Muscle Fatigue

Abstract

We tested if ACL-reconstructed participants show a decreased quadriceps torque, a lower muscle endurance capacity and a higher peak torque variability compared to unimpaired control participants prior to and following local muscle fatigue. Participants (n?=?19, 10 women; 25?±?5yrs.) with unilateral hamstrings autograft ACL-reconstruction and a matched unimpaired control group were recruited. Participants performed two maximal isometric voluntary force (MIVF) contractions of the knee extensors. In between, standardized local muscle fatigue was induced. ACL-reconstructed knees display a lower peak torque of the knee extensors in comparison to the contralateral limb (3.2?±?.3Nm/kg vs. 3.5?±?.3 Nm/kg). Peak torque variability and fatigue resistance were not affected by local muscle fatigue (p > .05). Participants with ACL-reconstructed knees show a persistent quadriceps muscle dysfunction. This dysfunction and lower limb side asymmetries might be risk factors for ACL re-ruptures.     

An Experimental Test of the Effects of Parental Modeling on Panic-Relevant Escape and Avoidance Among Early Adolescents

Escape and avoidance behaviors play a prominent role in the maintenance and possibly development of panic disorder, yet the literature regarding the etiology of these emotion-regulation strategies is relatively underdeveloped. The current study experimentally tests hypotheses that parental modeling of escape during a well-established panic-relevant biological challenge increases panic-relevant escape and avoidance among offspring. Fifty physically and psychologically healthy early adolescents (28 females; M_age = 11.58; 86% Caucasian), stratified by gender, were randomly assigned to observe one of their parents (39 females; M_age = 40.04): either (a) model completing a 3-min voluntary hyperventilation exercise (no escape modeling group) or (b) model premature termination of a similar procedure (escape modeling group). Offspring in the escape modeling group demonstrated a stronger escape response by discontinuing their own challenge sooner than those in the no-escape modeling group (r = .70). No group differences emerged in terms of avoidance responding, as indexed by nearly identical responding in terms of delay time before initiating the challenge, respiration rate, and self-reported willingness to engage in a second proposed challenge. Results suggest that parental behaviors may play an important role in the development of some forms of panic-relevant responding. These preliminary findings may have important implications for future prevention programs targeting parents and at-risk youth.     

When do employees cross boundaries? Individual and contextual determinants of career mobility

This study investigates the joint effects of individual characteristics and the labour market on career mobility. We propose that level of education, openness to experience, and a favourable labour market relate positively to employees crossing organizational, industrial, and occupational boundaries. Management programme alumni (N = 503) provided information through an online survey about their career histories, their level of education, and their openness to experience. Additionally, we used the unemployment rate as an indicator for yearly changes in the labour market. The results of our cross-classified multilevel analysis indicate that both individual characteristics and the labour market are determinants of career mobility. Level of education had a positive effect on organizational and industrial boundary crossing, and changes in the labour market related to organizational boundary crossing. Against our assumptions, openness to experience had no effect on career mobility, and none of the predictors were related to occupational boundary crossing. Our results demonstrate the importance of investigating career mobility from a boundary perspective combined with a focus on both individual and contextual characteristics. The dominance of education compared to personality and the difficulty of explaining occupational mobility open new research avenues and yield practical implications for employees, career counsellors, and organizations.     

What is the Accordion Effect?

In "Action and Responsibility,' Joel Feinberg pointed to an important idea to which he gave the label "the accordion effect.' Feinberg's discussion of this idea is of interest on its own, but it is also of interest because of its interaction with his critique, in his "Causing Voluntary Actions,' of a much discussed view of H. L. A. Hart and A. M. Honoré that Feinberg labels the "voluntary intervention principle.' In this essay I reflect on what the accordion effect is supposed by Feinberg to be, on differences between Feinberg's understanding of this idea and that of Donald Davidson, and on the interaction between Feinberg's discussion of the accordion effect and his critique of the voluntary intervention principle.     

J. S. Mill on Coolie Labour and Voluntary Slavery

This article discusses John Stuart Mill's voluntary slavery argument in On Liberty. The author shows that standard interpretations of the argument rely on the assumption that part of Mill's objection to voluntary slavery is the permanent nature of the decision. However, in correspondence, Mill also objects to voluntary ‘coolie’ labour contracts, which he regards as a form of slavery. This produces difficulties for standard interpretations of the voluntary slavery argument. Finally, the author provides a revised interpretation of Mill's argument to solve this problem.     

Response to Commentaries: Actions as Perceptual-Conceptual "Gestalts"

The author clarifies the objective and essence of the psychological, or perceptual-cognitive, approach to voluntary movement. According to that approach, voluntary movements are organized and performed as meaningful, perceptible events with bodily and environmental aspects. Body-oriented control is thus not neglected in the perceptual-cognitive approach but is actually an important issue. He further clarifies how material and psychological factors relate to each other in motor control and why they are not considered a coalition of constraints. The central importance of the sparse coding principle for the perceptual-cognitive approach is underlined. Finally, the author argues that the psychological information format is particularly suitable for motion control and stresses the power of the perceptual-cognitive approach to possibly provide a unifying framework for understanding human voluntary movements.     

Oscillations in Motor Priming: Positive Rebound Follows the Inhibitory Phase in the Masked Prime Paradigm

From among the diverse meanings of stability, the one the author adopts here is that the effects of a perturbation are opposed, and therefore small effects remain small. Except in linear systems, however, instability need not lead to unbounded motion and may actually be desirable when maneuverability is important. Moreover, properties of nerves, muscles, and tendons present serious challenges to stabilization. A review of observations from the motor control literature reveals that responses to perturbations in many common situations assist rather than resist the perturbation and are therefore presumably destabilizing. The observations encompass situations of position maintenance as well as impending or ongoing movement. The author proposes that the motor control system responds to a sudden perturbation by a pattern of muscle activity that mimics an accustomed voluntary movement, oblivious of stability considerations. What prevents runaway motion in the face of short-term instability appears to be voluntary intervention.