背外侧前额叶对主动遗忘负性社会反馈的作用：针对抑郁症的TMS研究

抑郁症患者的负性心境可能源于其抑制功能障碍。患者在主动遗忘负性材料时无法有效调用背外侧前额叶(the dorsolateral prefrontal cortex, DLPFC)等负责抑制控制的额叶脑网络。同时, 患者对社会信息的加工比对非社会信息的加工存在更明显的认知神经障碍, 很难主动遗忘对自己不利的社会反馈信息。为了提高抑郁症患者对负性社会反馈的主动遗忘能力, 本研究采用经颅磁刺激技术(transcranial magnetic stimulation, TMS), 考察抑郁症患者在左侧(n = 32)或右侧DLPFC (n = 30)被激活后其记忆控制能力的改变。结果表明, 当患者的DLPFC被TMS激活时, 他们对社会拒绝的回忆正确率与健康对照组(n = 31)无差异, 且TMS激活右侧DLPFC还改善了患者对他人的社会态度。本研究是采用TMS提高抑郁症患者主动遗忘能力的首次尝试, 研究结果不但支持了DLPFC与记忆控制功能的因果关系, 还为临床治疗抑郁症、创伤后应激障碍、药物成瘾等患者的记忆控制缺陷提供了明确的神经靶点。     

The effect of unilateral hand contractions on psychophysiological activity during motor performance: Evidence of verbal-analytical engagement

ObjectivesConscious engagement in movement control can influence motor performance. In most cases, the left hemisphere of the brain plays an important role in verbal-analytical processing and reasoning, so changes in the balance of hemispheric activation may influence conscious engagement in movement. Evidence suggests that unilateral hand contractions influence hemispheric activation, but no study has investigated whether there is an associated effect of hand contractions on verbal-analytical processing during motor performance. This study utilized psychophysiological (and behavioural) measures to examine whether pre-performance unilateral hand contraction protocols change verbal-analytical engagement during motor performance.DesignA repeated measures crossover design was employed.MethodsTwenty-eight participants completed three hand contraction protocols in a randomised order: left-, right- and no-hand contractions. Electroencephalography (EEG) measures of hemispheric asymmetry were computed during hand contractions. A golf putting task was conducted after each protocol. EEG connectivity between sites overlying the left verbal-analytical temporal region (T7) and the motor planning region (Fz) was computed for the 3 sec prior to movement initiation. Additionally, electrocardiography (ECG) and electromyography (EMG) signals were analysed 6 sec prior to movement initiation until 6 sec after. Golf putting performance (distance from the target) and putter swing kinematics were measured.ResultsContralateral hemisphere activity was revealed for the left-hand and right-hand contraction conditions. During motor planning, the left-hand contraction protocol led to significantly lower T7-Fz connectivity, and the right-hand contraction protocol led to significantly higher T7-Fz connectivity than the other conditions. EMG, ECG and kinematic measures did not differ as a function of condition. Importantly, T7-Fz connectivity mediated the relationship between hand squeezing and motor performance (distance from the target).ConclusionThe EEG results suggest that pre-performance unilateral hand contractions influence the extent of verbal-analytical engagement during motor planning, which in turn influences motor performance. However, the hand contractions did not influence cardiac activity, muscle activity or kinematics.     

Kripke Semantics, Undecidability and Standard Completeness for Esteva and Godo's Logic MTL∀

The present paper deals with the predicate version MTL of the logic MTL by Esteva and Godo. We introduce a Kripke semantics for it, along the lines of Ono's Kripke semantics for the predicate version of FL_ew (cf. [O85]), and we prove a completeness theorem. Then we prove that every predicate logic between MTL and classical predicate logic is undecidable. Finally, we prove that MTL is complete with respect to the standard semantics, i.e., with respect to Kripke frames on the real interval [0,1], or equivalently, with respect to MTL-algebras whose lattice reduct is [0,1] with the usual order.     

Coherentist Contraction

A model of coherentist belief contraction is constructed. The outcome of belief contraction is required to be one of the coherent subsets of the original belief set, and a set of plausible properties is proposed for this set of coherent subsets. The contraction operators obtained in this way are shown to coincide with well-known belief base operations. This connection between coherentist and foundationalist approaches to belief change has important implications for the philosophical interpretation of models of belief change.     

An evaluation of the ability to voluntarily reduce the heart rate after a month of yoga practice

The study aimed at determining whether novices to yoga would be able to reduce their heart rate voluntarily and whether the magnitude of reduction would be more after 30 days of yoga training. Two groups (yoga and control,n=12 each) were assessed on Day 1 and on Day 30. During the intervening 30 days, the yoga group received training in yoga techniques while the control group carried on with their routine. At each assessment the baseline heart rate was recorded for one minute, this was followed by a six-minute period during which participants were asked to attempt to voluntarily reduce their heart rate, using any strategy. Both the baseline heart rate and the lowest heart rate achieved voluntarily during the six-minute period were significantly lower in the yoga group on Day 30 compared to Day 1 by a group average of 10.7 beats per minute (i.e., bpm) and 6.8 bpm, respectively (p<.05, Wilcoxon paired signed ranks test). In contrast, there was no significant change in either the baseline heart rate or the lowest heart rate achieved voluntarily in the control group on Day 30 compared to Day 1. The results suggest that yoga training can enable practitioners to use their own strategies to reduce the heart rate, which has possible therapeutic applications.     

Severe Withdrawal (and Recovery)

The problem of how to remove information from an agent's stock of beliefs is of paramount concern in the belief change literature. An inquiring agent may remove beliefs for a variety of reasons: a belief may be called into doubt or the agent may simply wish to entertain other possibilities. In the prominent AGM framework for belief change, upon which the work here is based, one of the three central operations, contraction, addresses this concern (the other two deal with the incorporation of new information). Makinson has generalised this work by introducing the notion of a withdrawal operation. Underlying the account proffered by AGM is the idea of rational belief change. A belief change operation should be guided by certain principles or integrity constraints in order to characterise change by a rational agent. One of the most noted principles within the context of AGM is the Principle of Informational Economy. However, adoption of this principle in its purest form has been rejected by AGM leading to a more relaxed interpretation. In this paper, we argue that this weakening of the Principle of Informational Economy suggests that it is only one of a number of principles which should be taken into account. Furthermore, this weakening points toward a Principle of Indifference. This motivates the introduction of a belief removal operation that we call severe withdrawal. We provide rationality postulates for severe withdrawal and explore its relationship with AGM contraction. Moreover, we furnish possible worlds and epistemic entrenchment semantics for severe withdrawals.     

Quadriceps Torque,Peak Variability and Strength Endurance in Patients after Anterior Cruciate Ligament Reconstruction: Impact of Local Muscle Fatigue

Abstract

We tested if ACL-reconstructed participants show a decreased quadriceps torque, a lower muscle endurance capacity and a higher peak torque variability compared to unimpaired control participants prior to and following local muscle fatigue. Participants (n?=?19, 10 women; 25?±?5yrs.) with unilateral hamstrings autograft ACL-reconstruction and a matched unimpaired control group were recruited. Participants performed two maximal isometric voluntary force (MIVF) contractions of the knee extensors. In between, standardized local muscle fatigue was induced. ACL-reconstructed knees display a lower peak torque of the knee extensors in comparison to the contralateral limb (3.2?±?.3Nm/kg vs. 3.5?±?.3 Nm/kg). Peak torque variability and fatigue resistance were not affected by local muscle fatigue (p > .05). Participants with ACL-reconstructed knees show a persistent quadriceps muscle dysfunction. This dysfunction and lower limb side asymmetries might be risk factors for ACL re-ruptures.     

An Experimental Test of the Effects of Parental Modeling on Panic-Relevant Escape and Avoidance Among Early Adolescents

Escape and avoidance behaviors play a prominent role in the maintenance and possibly development of panic disorder, yet the literature regarding the etiology of these emotion-regulation strategies is relatively underdeveloped. The current study experimentally tests hypotheses that parental modeling of escape during a well-established panic-relevant biological challenge increases panic-relevant escape and avoidance among offspring. Fifty physically and psychologically healthy early adolescents (28 females; M_age = 11.58; 86% Caucasian), stratified by gender, were randomly assigned to observe one of their parents (39 females; M_age = 40.04): either (a) model completing a 3-min voluntary hyperventilation exercise (no escape modeling group) or (b) model premature termination of a similar procedure (escape modeling group). Offspring in the escape modeling group demonstrated a stronger escape response by discontinuing their own challenge sooner than those in the no-escape modeling group (r = .70). No group differences emerged in terms of avoidance responding, as indexed by nearly identical responding in terms of delay time before initiating the challenge, respiration rate, and self-reported willingness to engage in a second proposed challenge. Results suggest that parental behaviors may play an important role in the development of some forms of panic-relevant responding. These preliminary findings may have important implications for future prevention programs targeting parents and at-risk youth.     

What is the Accordion Effect?

In "Action and Responsibility,' Joel Feinberg pointed to an important idea to which he gave the label "the accordion effect.' Feinberg's discussion of this idea is of interest on its own, but it is also of interest because of its interaction with his critique, in his "Causing Voluntary Actions,' of a much discussed view of H. L. A. Hart and A. M. Honoré that Feinberg labels the "voluntary intervention principle.' In this essay I reflect on what the accordion effect is supposed by Feinberg to be, on differences between Feinberg's understanding of this idea and that of Donald Davidson, and on the interaction between Feinberg's discussion of the accordion effect and his critique of the voluntary intervention principle.